Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial

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SHIDFAR FARZAD; MOUSAVI SEYEDEH NEDA; Lorvand Amiri Hamid; AGAH SHAHRAM; HOSSEINI SHARIEH; Hajimiresmail Seyed Javad

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 496-505

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Title

Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial

Author(s)

Keywords

Calcium

Vitamin D

Atherogenic indices

Non-alcoholic fatty liver

Supplementation

Abstract

The role of Non-alcoholic fatty liver disease (NAFLD) as a potential independent cardiovascular disease (CVD) risk factor has recently gained considerable attention because CVD is the common cause of death in NAFLD patients. We aimed to estimate the effects of Vitamin D Supplementation alone or in combination with Calcium on Atherogenic indices, liver function tests, and grade of disease in patients with NAFLD. One-hundred twenty NAFLD patients were randomized in a double-blind, placebo-controlled clinical trial as follows: D (1000 IU Vitamin D), CaD (500 mg as Calcium carbonate plus 1000 IU Vitamin D) or P (placebo), once daily with meals over 12 weeks. Adjusted for all the baseline measures, reduction in serum ALT, AST, LDL-C/HDL-C, TC/HDL-C, and non-HDL-C were significantly higher in the CaD compared with the P group (p < 0. 001, p = 0. 03, p < 0. 001, p < 0. 001, p < 0. 001 and p < 0. 001, respectively). Also, mean difference of serum ALT, LDL-C/HDL-C, TC/HDL-C, and TG/HDL-C were significantly higher in the CaD than D group (p < 0. 001, p = 0. 006, p < 0. 001 and p = 0. 03, respectively). Serum non-HDL-C was marginally decreased in the CaD compared with the D group (p = 0. 06). With considering the BMI changes as covariate, reduction in the grade of fatty liver was significantly higher in the CaD and D groups than the P (p < 0. 001). The present study suggests that supplemental Calcium combined with Vitamin D, but not Vitamin D alone, may reduce serum Atherogenic indices, liver function tests, and grade of disease in patients with NAFLD.

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APA: Copy

SHIDFAR, FARZAD, MOUSAVI, SEYEDEH NEDA, Lorvand Amiri, Hamid, AGAH, SHAHRAM, HOSSEINI, SHARIEH, & Hajimiresmail, Seyed Javad. (2019). Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 496-505. SID. https://sid.ir/paper/289221/en

Vancouver: Copy

SHIDFAR FARZAD, MOUSAVI SEYEDEH NEDA, Lorvand Amiri Hamid, AGAH SHAHRAM, HOSSEINI SHARIEH, Hajimiresmail Seyed Javad. Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):496-505. Available from: https://sid.ir/paper/289221/en

IEEE: Copy

FARZAD SHIDFAR, SEYEDEH NEDA MOUSAVI, Hamid Lorvand Amiri, SHAHRAM AGAH, SHARIEH HOSSEINI, and Seyed Javad Hajimiresmail, “Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 496–505, 2019, [Online]. Available: https://sid.ir/paper/289221/en

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