EFFECTS OF CIGARETTE SMOKE EXTRACT (CSE) ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION

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KAVOLI HAGHIGHI M.; POLLOCK D.

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Journal: Hakim Journal Year:2002 | Volume:4 | Issue:4 Page(s): 284-290

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Information Journal Paper

Title

EFFECTS OF CIGARETTE SMOKE EXTRACT (CSE) ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION

Author(s)

KAVOLI HAGHIGHI M. | POLLOCK D. | Issue Writer Certificate

Keywords

ENDOTHELIUMQ4

NITRIC OXIDEQ4

CIGARETTE SMOKE EXTRACTQ4

ACETYLCHOLINEQ4

NITROPRUSSIDE SODIUMQ4

PHENYLEPHLINEQ4

Abstract

Cigarette smoking has been implicated as a major risk factor in chronic obstructive pulmonary disease, chronic hypoxic cor pulmonale, atherosclerosis, and related cardiovascular dysfunction. The mechanism for increased risk of vascular dysfunction due to smoking is not well understood, but it is presumed to be due to the absorption of tobacco smoke constituents that effect endothelial cell function. The purpose of this study was to investigate the effects of CIGARETTE SMOKE EXTRACT on the rat pulmonary artery rings responses to ENDOTHELIUM-dependent relaxant (acetylcholine), ENDOTHELIUM-independent relaxant (nitroprusside sodium) and also to vasoconstrictor agent (phenylephrine). In this study, concentration-dependent responses of rat's pulmonary artery rings precontracted with 100 nanomol phenylephrine were tested to ACETYLCHOLINE and NITROPRUSSIDE SODIUM in the absence and presence of 0.1 ml of CIGARETTE SMOKE EXTRACT. The responses were recorded isometrically with Grass FTO3 transducers and were displayed on a Grass model 7 polygraph. The findings of this study demonstrated that 0.1 milliliter of cigarette smoke depresed-endothium-dependent relaxant ACETYLCHOLINE responses but did not effect on ENDOTHELIUM-independent relaxant responses. Also contractile responses to phenylephl1ne depressed by 2 ml of CIGARETTE SMOKE EXTRACT; while they did not affect by 0.1 and 1 ml of CIGARETTE SMOKE EXTRACT. In conclusion the results obtained in this study indicated that CIGARETTE SMOKE EXTRACT impairs ENDOTHELIUM-dependent relaxant responses of the rat pulmonary artery lings; but did not mpair ENDOTHELIUM-independent relaxant responses.

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APA: Copy

KAVOLI HAGHIGHI, M., & POLLOCK, D.. (2002). EFFECTS OF CIGARETTE SMOKE EXTRACT (CSE) ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION. HAKIM RESEARCH JOURNAL, 4(4), 284-290. SID. https://sid.ir/paper/29091/en

Vancouver: Copy

KAVOLI HAGHIGHI M., POLLOCK D.. EFFECTS OF CIGARETTE SMOKE EXTRACT (CSE) ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION. HAKIM RESEARCH JOURNAL[Internet]. 2002;4(4):284-290. Available from: https://sid.ir/paper/29091/en

IEEE: Copy

M. KAVOLI HAGHIGHI, and D. POLLOCK, “EFFECTS OF CIGARETTE SMOKE EXTRACT (CSE) ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION,” HAKIM RESEARCH JOURNAL, vol. 4, no. 4, pp. 284–290, 2002, [Online]. Available: https://sid.ir/paper/29091/en

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