EVALUATION OF ANTI- HLA CLASS I ANTIBODIES IN CHRONIC REJECTION OF KIDNEY TRANSPLANTATION

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NIKNAM M.H.; TORKASHVAND A.R.; AMIRZARGAR ALI AKBAR; KHOSRAVI F.; NIKBIN B.; GHODS A.; AMIRKHANI A.

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2004 | Volume:3 | Issue:2 Page(s): 65-69

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Title

EVALUATION OF ANTI- HLA CLASS I ANTIBODIES IN CHRONIC REJECTION OF KIDNEY TRANSPLANTATION

Author(s)

Keywords

ANTI-HLA ANTIBODIES

KIDNEY TRANSPLANTATION

REJECTION

Abstract

Studies have shown that patients who do not produce donor specific and / or panel reactive ANTI-HLA ANTIBODIES have a longer graft survival. The purpose of this study was to evaluate the post transplant humoral immune response towards HLA-class I antigens and the measurement of the serum creatinine levels which are used in monitoring posttransplant function of kidney. Serum samples from 132 renal transplant recipients were screened for preformed anti-HLA class I panel reactive antibodies (PRA) by means of microlymphocytotoxicity assay. The results revealed the presence of PRA in 26 (19.7%) out of 132 transplanted patients. Graft function was evaluated by measurement of serum creatinine levels which revealed the mean of 1.75 mg/dl (SD: 1.08). Because of clinical significance of presence of different PRA amounts (>10%, > 20% and >50% of panel reactivity) in patients, correlation with kidney function status was analyzed. The obtained data highlighted a higher presence of serum creatinine levels in PRA-positive patients compared to negative patients (P<0.01).These results (and further studies for class II, …) can be used to implement new therapeutic strategies to curtail post transplant alloantibodies production and better allografts survival.

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APA: Copy

NIKNAM, M.H., TORKASHVAND, A.R., AMIRZARGAR, ALI AKBAR, KHOSRAVI, F., NIKBIN, B., GHODS, A., & AMIRKHANI, A.. (2004). EVALUATION OF ANTI- HLA CLASS I ANTIBODIES IN CHRONIC REJECTION OF KIDNEY TRANSPLANTATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 3(2), 65-69. SID. https://sid.ir/paper/291060/en

Vancouver: Copy

NIKNAM M.H., TORKASHVAND A.R., AMIRZARGAR ALI AKBAR, KHOSRAVI F., NIKBIN B., GHODS A., AMIRKHANI A.. EVALUATION OF ANTI- HLA CLASS I ANTIBODIES IN CHRONIC REJECTION OF KIDNEY TRANSPLANTATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2004;3(2):65-69. Available from: https://sid.ir/paper/291060/en

IEEE: Copy

M.H. NIKNAM, A.R. TORKASHVAND, ALI AKBAR AMIRZARGAR, F. KHOSRAVI, B. NIKBIN, A. GHODS, and A. AMIRKHANI, “EVALUATION OF ANTI- HLA CLASS I ANTIBODIES IN CHRONIC REJECTION OF KIDNEY TRANSPLANTATION,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 3, no. 2, pp. 65–69, 2004, [Online]. Available: https://sid.ir/paper/291060/en

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