HLA CLASS II ALLELE AND HAPLOTYPE FREQUENCIES IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA AND CONTROL GROUP

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SARAFNEZHAD A.; KHOSRAVI F.; ALI MOGHADAM K.; DIANAT S.; ANSARIPOUR B.; MORADI B.; DORKHOUSH SH.; AMIRZARGAR ALI AKBAR

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2006 | Volume:5 | Issue:3 Page(s): 115-119

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Title

HLA CLASS II ALLELE AND HAPLOTYPE FREQUENCIES IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA AND CONTROL GROUP

Author(s)

Keywords

ACUTE MYELOGENOUS LEUKEMIA

HLA CLASS II

POLYMORPHISM

Abstract

Previous studies have demonstrated some significant differences in HLA allele frequencies in leukemic patients and normal subjects. We have analyzed HLA CLASS II alleles and haplotypes in 60 Iranian patients with ACUTE MYELOGENOUS LEUKEMIA (AML) and 180 unrelated normal subjects. Blood samples were collected after obtaining informed consents. From the patients and control DNA extraction and HLA typing were performed using PCR-SSP method. Significant positive association with the disease was found for HLA-DRB1*11 allele (35% vs. 24.7%, p=0.033). Two alleles including HLA-DRB4 and –DQB1*0303 were found to be significantly decreased in patients compared to controls. Regarding haplotype analysis, no significant association was found between case and control groups. It is suggested that HLA-DRB1*11 allele plays as a presumptive predisposing factor while the HLA-DRB4 and –DQB1*0303 alleles are suggested as protective genetic factors against ACUTE MYELOGENOUS LEUKEMIA. Larger studies are needed to confirm and establish the role of these associations with ACUTE MYELOGENOUS LEUKEMIA.

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APA: Copy

SARAFNEZHAD, A., KHOSRAVI, F., ALI MOGHADAM, K., DIANAT, S., ANSARIPOUR, B., MORADI, B., DORKHOUSH, SH., & AMIRZARGAR, ALI AKBAR. (2006). HLA CLASS II ALLELE AND HAPLOTYPE FREQUENCIES IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA AND CONTROL GROUP. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 5(3), 115-119. SID. https://sid.ir/paper/291132/en

Vancouver: Copy

SARAFNEZHAD A., KHOSRAVI F., ALI MOGHADAM K., DIANAT S., ANSARIPOUR B., MORADI B., DORKHOUSH SH., AMIRZARGAR ALI AKBAR. HLA CLASS II ALLELE AND HAPLOTYPE FREQUENCIES IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA AND CONTROL GROUP. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2006;5(3):115-119. Available from: https://sid.ir/paper/291132/en

IEEE: Copy

A. SARAFNEZHAD, F. KHOSRAVI, K. ALI MOGHADAM, S. DIANAT, B. ANSARIPOUR, B. MORADI, SH. DORKHOUSH, and ALI AKBAR AMIRZARGAR, “HLA CLASS II ALLELE AND HAPLOTYPE FREQUENCIES IN IRANIAN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA AND CONTROL GROUP,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 5, no. 3, pp. 115–119, 2006, [Online]. Available: https://sid.ir/paper/291132/en

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