ASSOCIATION OF THE EXPRESSION OF IL-4 AND IL-13 GENES, IL-4 AND IGE SERUM LEVELS WITH ALLERGIC ASTHMA

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TAVAKOL AFSHARI J.; HOSSEINI FARAHABADI S.; KHOSHNAVAZI R.; GHAYOUR KARIMIANI E.; GHASSEMI GH.R.; FARID HOSSEINI R.; HEYDARIAN FARHAD; BOSKABADI M.H.; RAZAVI A.R.

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2007 | Volume:6 | Issue:2 Page(s): 67-72

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Title

ASSOCIATION OF THE EXPRESSION OF IL-4 AND IL-13 GENES, IL-4 AND IGE SERUM LEVELS WITH ALLERGIC ASTHMA

Author(s)

Keywords

ASTHMA

GENES

IL-4

IL-13

RT-PCR

Abstract

Immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of ASTHMA. These responses are associated with overexpression of Th2 cytokines such as IL-4 and IL-13. These two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the Th1/Th2 balance. The aim of this study was to determine whether patients with allergic ASTHMA display overexpression of IL-4 and IL-13 GENES. Using RT-PCR, we examined the expression of IL-4 and IL-13 GENES in twenty ASTHMAtic cases and twenty normal individuals. Total levels of serum IgE and IL-4 were also determined by ELISA method. Expression of IL-13 gene in 70% of patients with allergic ASTHMA was higher than controls (P=0.01). There was no correlation between the expression of IL-13 gene and total level of serum IgE (P=0.07). Expression of IL-4 gene was detected in 30% of the patients and none of the normal individuals as determined by RT-PCR (P=0.01). Mean of serum IgE levels in patients and controls were 84.9 IU/ml and 62.2 IU/ml, respectively. Level of serum IgE was more than 100 IU/ml in 30% of patients (P=0.03). Mean of serum IL-4 levels in patients and controls were 15.73 pg/ml and 13.07 pg/ml, respectively. There was a relation between levels of serum IgE and IL-4 in 73% of cases. The results showed that there was a correlation between the expression of IL-4 gene and the level of serum IL-4. Levels of serum IgE and IL-4 were considerably higher in ASTHMAtics than non-ASTHMAtic controls.

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APA: Copy

TAVAKOL AFSHARI, J., HOSSEINI FARAHABADI, S., KHOSHNAVAZI, R., GHAYOUR KARIMIANI, E., GHASSEMI, GH.R., FARID HOSSEINI, R., HEYDARIAN, FARHAD, BOSKABADI, M.H., & RAZAVI, A.R.. (2007). ASSOCIATION OF THE EXPRESSION OF IL-4 AND IL-13 GENES, IL-4 AND IGE SERUM LEVELS WITH ALLERGIC ASTHMA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 6(2), 67-72. SID. https://sid.ir/paper/291163/en

Vancouver: Copy

TAVAKOL AFSHARI J., HOSSEINI FARAHABADI S., KHOSHNAVAZI R., GHAYOUR KARIMIANI E., GHASSEMI GH.R., FARID HOSSEINI R., HEYDARIAN FARHAD, BOSKABADI M.H., RAZAVI A.R.. ASSOCIATION OF THE EXPRESSION OF IL-4 AND IL-13 GENES, IL-4 AND IGE SERUM LEVELS WITH ALLERGIC ASTHMA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2007;6(2):67-72. Available from: https://sid.ir/paper/291163/en

IEEE: Copy

J. TAVAKOL AFSHARI, S. HOSSEINI FARAHABADI, R. KHOSHNAVAZI, E. GHAYOUR KARIMIANI, GH.R. GHASSEMI, R. FARID HOSSEINI, FARHAD HEYDARIAN, M.H. BOSKABADI, and A.R. RAZAVI, “ASSOCIATION OF THE EXPRESSION OF IL-4 AND IL-13 GENES, IL-4 AND IGE SERUM LEVELS WITH ALLERGIC ASTHMA,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 6, no. 2, pp. 67–72, 2007, [Online]. Available: https://sid.ir/paper/291163/en

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