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Title

HIGH PRODUCTION OF IL-18 BY DENDRITIC CELLS INDUCED BY SERA FROM PATIENTS WITH PRIMARY ANTIBODY DEFICIENCY

Pages

  59-65

Abstract

 Predominantly antibody deficiencies are a category of primary immunodeficiency diseases, which consist of several rare disorders such as COMMON VARIABLE IMMUNODEFICIENCY (CVID) and X-LINKED AGAMMAGLOBULINEMIA (XLA). We evaluated the effects of CVID and XLA patients’ sera as a source of microenviromental factors on maturation and function of monocyte-derived DCs. Blood was collected from 10 CVID and 5 XLA patients before immunoglobulin replacement therapy and also from 8 healthy volunteers in order to obtain necessary sera for this study. Monocyte derived DCs were generated from blood cells obtained from healthy volunteers in the presence of GM-CSF, IL-4 and 10% serum concentrations from cases and controls. Immature DCs were incubated with monocyte conditioned medium (MCM) and TNF-a in order to generate mature DCs. Interleukin 18 (IL-18) production by CD40L-activated mature DCs was measured after 24 hours of culture in vitro.IL-18 production by DCs generated in the presence of CVID and XLA patients’ sera were 6.75±2.59 and 7.08±1.75 ng/ml, respectively, which were significantly higher than normal serum conditioned DCs (3.55±0.68) ng/ml. These results suggest that the sera of patients with predominantly antibody deficiencies may contain soluble factor(s) that can induce a significant increase in IL-18 production by DCs.

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    APA: Copy

    NOURIZADEH, M., AGHAMOHAMMADI, A., REZAEI, N., MOAZENI, S.M., & HAJATI, JAMSHID. (2007). HIGH PRODUCTION OF IL-18 BY DENDRITIC CELLS INDUCED BY SERA FROM PATIENTS WITH PRIMARY ANTIBODY DEFICIENCY. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 6(2), 59-65. SID. https://sid.ir/paper/291166/en

    Vancouver: Copy

    NOURIZADEH M., AGHAMOHAMMADI A., REZAEI N., MOAZENI S.M., HAJATI JAMSHID. HIGH PRODUCTION OF IL-18 BY DENDRITIC CELLS INDUCED BY SERA FROM PATIENTS WITH PRIMARY ANTIBODY DEFICIENCY. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2007;6(2):59-65. Available from: https://sid.ir/paper/291166/en

    IEEE: Copy

    M. NOURIZADEH, A. AGHAMOHAMMADI, N. REZAEI, S.M. MOAZENI, and JAMSHID HAJATI, “HIGH PRODUCTION OF IL-18 BY DENDRITIC CELLS INDUCED BY SERA FROM PATIENTS WITH PRIMARY ANTIBODY DEFICIENCY,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 6, no. 2, pp. 59–65, 2007, [Online]. Available: https://sid.ir/paper/291166/en

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