THE OPPOSITE ASSOCIATIONS OF LYCOPENE AND BODY FAT MASS WITH HUMORAL IMMUNITY IN TYPE 2 DIABETES MELLITUS: A POSSIBLE ROLE IN ATHEROGENESIS

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NEYESTANI T.R.; SHARIATZADEH N.; GHARAVI A.; KALAEI A.; KHALAJI N.

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2007 | Volume:6 | Issue:2 Page(s): 79-87

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Title

THE OPPOSITE ASSOCIATIONS OF LYCOPENE AND BODY FAT MASS WITH HUMORAL IMMUNITY IN TYPE 2 DIABETES MELLITUS: A POSSIBLE ROLE IN ATHEROGENESIS

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Keywords

DIABETES MELLITUS TYPE 2

FAT MASS

IMMUNITY

LYCOPENE

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Abstract

This study examined the possible effects of LYCOPENE at physiological dosage and body FAT MASS on the humoral immune response in patients with type 2 diabetes mellitus (T2DM). A total of 35 patients with Typ 2 diabetes mellitus from both sexes aged 54±9 yrs from the Iranian Diabetes Society were introduced into a double blind placebo controlled clinical trial conducted for 2 months. After a 2-week LYCOPENE free diet washout period, patients were allocated to either LYCOPENE supplementation group (10mg/d) (n=16) or placebo age- and sex matched group (n=19) for 8 weeks. Patients were instructed to keep their diets and physical activities as unchanged as possible. LYCOPENE supplements increased serum LYCOPENE levels (p<0.001). While intake of dietary energy and nutrients did not change in either groups, the ratio of total antioxidant capacity to malondialdehyde increased significantly in the LYCOPENE group (p=0.007). There was an inverse correlation between serum levels of LYCOPENE and those of IgG (r= -0.338, p=0.008). On the contrary, changes of serum levels of LYCOPENE directly correlated with those of IgM (r=0.466, p=0.005). Interestingly, changes of the amount of FAT MASS correlated directly with those of serum IgG (r=0.415, p=0.044) but inversely with of serum IgM (r= -0.469, p=0.021). While truncal fat might promote adaptive humoral IMMUNITY, LYCOPENE probably by inhibiting MDA-LDL formation might attenuate T cell dependent adaptive (pro-atherogenic) humoral immune response. These findings may have preventive implications in long term diabetic complications, notably atherogenesis.

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APA: Copy

NEYESTANI, T.R., SHARIATZADEH, N., GHARAVI, A., KALAEI, A., & KHALAJI, N.. (2007). THE OPPOSITE ASSOCIATIONS OF LYCOPENE AND BODY FAT MASS WITH HUMORAL IMMUNITY IN TYPE 2 DIABETES MELLITUS: A POSSIBLE ROLE IN ATHEROGENESIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 6(2), 79-87. SID. https://sid.ir/paper/291168/en

Vancouver: Copy

NEYESTANI T.R., SHARIATZADEH N., GHARAVI A., KALAEI A., KHALAJI N.. THE OPPOSITE ASSOCIATIONS OF LYCOPENE AND BODY FAT MASS WITH HUMORAL IMMUNITY IN TYPE 2 DIABETES MELLITUS: A POSSIBLE ROLE IN ATHEROGENESIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2007;6(2):79-87. Available from: https://sid.ir/paper/291168/en

IEEE: Copy

T.R. NEYESTANI, N. SHARIATZADEH, A. GHARAVI, A. KALAEI, and N. KHALAJI, “THE OPPOSITE ASSOCIATIONS OF LYCOPENE AND BODY FAT MASS WITH HUMORAL IMMUNITY IN TYPE 2 DIABETES MELLITUS: A POSSIBLE ROLE IN ATHEROGENESIS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 6, no. 2, pp. 79–87, 2007, [Online]. Available: https://sid.ir/paper/291168/en

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