EVALUATION OF HUMORAL IMMUNE FUNCTION IN PATIENTS WITH BRONCHIECTASIS

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TABATABAEI P.; AGHAMOHAMMADI A.; MAMISHI S.; ISAEIAN A.; HEYDARI GOLNAZ; ABD ELAH ZADEH S.; PIROUZI P.; REZAEI NIMA; HEYDARNEZHAD H.; MIRSAEID GHAZI B.; YEGANEH M.; CHERAGHI T.; ABOU ALHASANI H.; SAGHAFI SH.; ALIZADEH HOUMAN; ANARAKI M.R.

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Journal Paper

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2008 | Volume:7 | Issue:2 Page(s): 69-77

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Title

EVALUATION OF HUMORAL IMMUNE FUNCTION IN PATIENTS WITH BRONCHIECTASIS

Author(s)

Keywords

BRONCHIECTASIS

COMMON VARIABLE IMMUNODEFICIENCY

HUMORAL IMMUNITY

IGA DEFICIENCY

PRIMARY IMMUNODEFICIENCY

Abstract

BRONCHIECTASIS is a chronic debilitating condition characterized by abnormal dilated thick-walled bronchi. To investigate humoral immune function in bronchiectatic patients, this study was performed. Forty patients with established diagnosis of BRONCHIECTASIS, who were referred from two tertiary care pulmonology centers in Tehran, were investigated in this study. Immunoglobulin isotypes concentrations and IgG-subclasses were measured by nephelometry and enzyme-linked immunosorbent assay (ELISA) methods, respectively. All patients received unconjugated pneumococcal vaccine, and blood samples were taken before and 21 days after vaccination. Specific antibodies against whole pneumococcal antigens were measured using the ELISA method. Fifteen (37.5%) out of 40 patients were diagnosed to have defects in antibody mediated immunity including 5 (12.5%) patients with immunoglobulin class deficiency (2 with COMMON VARIABLE IMMUNODEFICIENCY and 3 with IGA DEFICIENCY), 3 (7.5%) with IgG subclass deficiency and 7 (17.5%) patients had Specific antibody deficiency (SAD) against polysaccharide antigen despite normal levels of serum immunoglobulins and IgG subclasses. Our study along with several other studies confirmed that all patients with BRONCHIECTASIS should undergo thorough immunological evaluation in order to identify the presence of the underlying immunologic defect. This evaluation should include serum immunoglobulins, IgG subclasses concentrations and also determination of serum antibodies against pneumococcal antigens. Early diagnosis and appropriate treatment will prevent the subsequent complications and improve quality of life of affected individuals.

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APA: Copy

TABATABAEI, P., AGHAMOHAMMADI, A., MAMISHI, S., ISAEIAN, A., HEYDARI, GOLNAZ, ABD ELAH ZADEH, S., PIROUZI, P., REZAEI, NIMA, HEYDARNEZHAD, H., MIRSAEID GHAZI, B., YEGANEH, M., CHERAGHI, T., ABOU ALHASANI, H., SAGHAFI, SH., ALIZADEH, HOUMAN, & ANARAKI, M.R.. (2008). EVALUATION OF HUMORAL IMMUNE FUNCTION IN PATIENTS WITH BRONCHIECTASIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 7(2), 69-77. SID. https://sid.ir/paper/291201/en

Vancouver: Copy

TABATABAEI P., AGHAMOHAMMADI A., MAMISHI S., ISAEIAN A., HEYDARI GOLNAZ, ABD ELAH ZADEH S., PIROUZI P., REZAEI NIMA, HEYDARNEZHAD H., MIRSAEID GHAZI B., YEGANEH M., CHERAGHI T., ABOU ALHASANI H., SAGHAFI SH., ALIZADEH HOUMAN, ANARAKI M.R.. EVALUATION OF HUMORAL IMMUNE FUNCTION IN PATIENTS WITH BRONCHIECTASIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2008;7(2):69-77. Available from: https://sid.ir/paper/291201/en

IEEE: Copy

P. TABATABAEI, A. AGHAMOHAMMADI, S. MAMISHI, A. ISAEIAN, GOLNAZ HEYDARI, S. ABD ELAH ZADEH, P. PIROUZI, NIMA REZAEI, H. HEYDARNEZHAD, B. MIRSAEID GHAZI, M. YEGANEH, T. CHERAGHI, H. ABOU ALHASANI, SH. SAGHAFI, HOUMAN ALIZADEH, and M.R. ANARAKI, “EVALUATION OF HUMORAL IMMUNE FUNCTION IN PATIENTS WITH BRONCHIECTASIS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 7, no. 2, pp. 69–77, 2008, [Online]. Available: https://sid.ir/paper/291201/en

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