ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH BRONCHIAL ASTHMA IN MACEDONIANS

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TRAJKOV D.; MIRKOVSKA STOJKOVIKI J.; ARSOV T.; PETLICHKOVSKI A.; STREZOVA A.; EFINSKA MLADENOVSKA O.; SANDEVSKA E.; GOGUSEV J.; SPIROSKI M.

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Journal Paper

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2008 | Volume:7 | Issue:3 Page(s): 143-156

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Title

ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH BRONCHIAL ASTHMA IN MACEDONIANS

Author(s)

Keywords

BRONCHIAL ASTHMA

CYTOKINE POLYMORPHISM

MACEDONIANS

Abstract

BRONCHIAL ASTHMA is a multifactorial disease whereby both environmental and genetic factors contribute to its aetiology and/or clinical severity. The aim of this study was to examine the association of 22 cytokine gene polymorphism in the Macedonian population with BRONCHIAL ASTHMA (BA).The sample of the population comprised of 301 normal unrelated individuals and 74 patients with BA. Cytokine genotyping was performed by PCR.Susceptible CYTOKINE POLYMORPHISMs for BA for ten genotypes (IL-4 -1098/T:T, TNF-a- 238/A:G, IL-4 -590/C:C, IL-2 +166/T:T, IL-2 -330/T:T, IL-10 -1082/G:G, IFNg utr5644/T:T, IL-10 -1082/A:A, IL-1b +3962/T:T, IL-6 -174/G:G), six diplotypes, four haplotypes, and two alleles were found. Protective CYTOKINE POLYMORPHISMs for BA for seven cytokine genotypes (IL-4 -1098/G:T, TNF- a-238/G:G, IL-2 -330/G:T, IL-4 -590/C:T, IFNg utr5644/ AT, IL-1b +3962/C:T, IL-10 -1082/A:G), six cytokine diplotypes, four cytokine haplotypes, and four cytokine alleles were found.We concluded that several CYTOKINE POLYMORPHISMs are protective, or susceptible associated with BA in population of MACEDONIANS.

Cites

ROLE OF THE IMMUNE CELLS, MEDIATORS AND CYTOKINES IN PATHOGENESIS OF ASTHMA: A REVIEW ARTICLE

References

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APA: Copy

TRAJKOV, D., MIRKOVSKA STOJKOVIKI, J., ARSOV, T., PETLICHKOVSKI, A., STREZOVA, A., EFINSKA MLADENOVSKA, O., SANDEVSKA, E., GOGUSEV, J., & SPIROSKI, M.. (2008). ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH BRONCHIAL ASTHMA IN MACEDONIANS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 7(3), 143-156. SID. https://sid.ir/paper/291207/en

Vancouver: Copy

TRAJKOV D., MIRKOVSKA STOJKOVIKI J., ARSOV T., PETLICHKOVSKI A., STREZOVA A., EFINSKA MLADENOVSKA O., SANDEVSKA E., GOGUSEV J., SPIROSKI M.. ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH BRONCHIAL ASTHMA IN MACEDONIANS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2008;7(3):143-156. Available from: https://sid.ir/paper/291207/en

IEEE: Copy

D. TRAJKOV, J. MIRKOVSKA STOJKOVIKI, T. ARSOV, A. PETLICHKOVSKI, A. STREZOVA, O. EFINSKA MLADENOVSKA, E. SANDEVSKA, J. GOGUSEV, and M. SPIROSKI, “ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH BRONCHIAL ASTHMA IN MACEDONIANS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 7, no. 3, pp. 143–156, 2008, [Online]. Available: https://sid.ir/paper/291207/en

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