HUMAN LEUKOCYTE ANTIGENS (HLA) ASSOCIATED WITH SELECTIVE IGA DEFICIENCY IN IRAN AND SWEDEN

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MOHAMMADI JAVAD; POURPAK Z.; JAREFORS S.; SAGHAFI SH.; ZENDEHDEL K.; AMIRZARGAR ALI AKBAR; AGHAMOHAMMADI A.; MOEIN MOSTAFA; HAMMARSTROM L.

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2008 | Volume:7 | Issue:4 Page(s): 209-214

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Title

HUMAN LEUKOCYTE ANTIGENS (HLA) ASSOCIATED WITH SELECTIVE IGA DEFICIENCY IN IRAN AND SWEDEN

Author(s)

Keywords

GENETIC BACKGROUND

HLA ANTIGENS

IGA DEFICIENCY

Abstract

Selective IGA DEFICIENCY (IgAD) (serum IgA concentration of <0.07 g/l) is the most common primary immunodeficiency in Caucasians, with an estimated prevalence of 1/600. There are strong indications for involvement of genetic factors in development of the disease and the frequency of several extended major histocompatibility complex haplotypes (including HLA-Al, B8, DR3, DQ2) have previously been shown to be increased among Caucasian patients with IgAD.PCR was used to type HLA B, DR, and DQ alleles in 29 Iranian individuals with IgAD and 299 Swedish individuals with IgAD.The results indicate a strong association with the HLA B14, DRl alleles in Iranian subjects and HLA B8, B12, B13, B14, B40, DR1, DR3, DR7, DQ2 and DQ5 allelesin Swedish subjects. Differences in HLA association of IgAD in Iran and Sweden confirm the notion of a GENETIC BACKGROUND of the disease and that multiple, potentially different genes within the MHC region might be involved in the pathogenesis of IgAD in different ethnic groups.

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APA: Copy

MOHAMMADI, JAVAD, POURPAK, Z., JAREFORS, S., SAGHAFI, SH., ZENDEHDEL, K., AMIRZARGAR, ALI AKBAR, AGHAMOHAMMADI, A., MOEIN, MOSTAFA, & HAMMARSTROM, L.. (2008). HUMAN LEUKOCYTE ANTIGENS (HLA) ASSOCIATED WITH SELECTIVE IGA DEFICIENCY IN IRAN AND SWEDEN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 7(4), 209-214. SID. https://sid.ir/paper/291219/en

Vancouver: Copy

MOHAMMADI JAVAD, POURPAK Z., JAREFORS S., SAGHAFI SH., ZENDEHDEL K., AMIRZARGAR ALI AKBAR, AGHAMOHAMMADI A., MOEIN MOSTAFA, HAMMARSTROM L.. HUMAN LEUKOCYTE ANTIGENS (HLA) ASSOCIATED WITH SELECTIVE IGA DEFICIENCY IN IRAN AND SWEDEN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2008;7(4):209-214. Available from: https://sid.ir/paper/291219/en

IEEE: Copy

JAVAD MOHAMMADI, Z. POURPAK, S. JAREFORS, SH. SAGHAFI, K. ZENDEHDEL, ALI AKBAR AMIRZARGAR, A. AGHAMOHAMMADI, MOSTAFA MOEIN, and L. HAMMARSTROM, “HUMAN LEUKOCYTE ANTIGENS (HLA) ASSOCIATED WITH SELECTIVE IGA DEFICIENCY IN IRAN AND SWEDEN,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 7, no. 4, pp. 209–214, 2008, [Online]. Available: https://sid.ir/paper/291219/en

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