مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE 14KDA PROTEIN MOLECULE ISOLATED FROM GARLIC SUPPRESSES INDOLEAMINE 2, 3- DIOXYGENASE METABOLITES IN MONONUCLEAR CELLS IN VITRO

Pages

  203-208

Abstract

 A wide range of biological activities of GARLIC in vitro and in vivo have been verified including its antioxidant, antitumor and anti-inflammatory effects. INDOLEAMINE 2, 3-DIOXYGENASE (IDO) is an enzyme widely distributed in mammals and is inducible preferentially by IFN-y. IDO degrades the essential amino acid TRYPTOPHAN to form N-formly kynurenine.In the present in vitro study, the modulatory effect of 14kDa molecule isolated from GARLIC on IDO induction was tested. Cultures of mononuclear cells were exposed to 14kDa GARLIC fraction. Then, their PROLIFERATION responses and IDO metabolites were measured. A significant down-regulatory effect of GARLIC on IDO activity was found and also the PROLIFERATION responses of mononuclear cells increased.If these results are verified in vivo, an explanation will be provided on how GARLIC may interfere in IDO induction, which paves the way for elucidating its specific therapeutic effect in preventing tumor progress.

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    APA: Copy

    NIKOU, SH., BOZORGMEHR, M., NAMDAR AHMADABAD, H., MOHAMMAD HASAN, ZOHEYR, MOAZENI, S.M., POURPAK, Z., & GHAZANFARI, T.. (2008). THE 14KDA PROTEIN MOLECULE ISOLATED FROM GARLIC SUPPRESSES INDOLEAMINE 2, 3- DIOXYGENASE METABOLITES IN MONONUCLEAR CELLS IN VITRO. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 7(4), 203-208. SID. https://sid.ir/paper/291223/en

    Vancouver: Copy

    NIKOU SH., BOZORGMEHR M., NAMDAR AHMADABAD H., MOHAMMAD HASAN ZOHEYR, MOAZENI S.M., POURPAK Z., GHAZANFARI T.. THE 14KDA PROTEIN MOLECULE ISOLATED FROM GARLIC SUPPRESSES INDOLEAMINE 2, 3- DIOXYGENASE METABOLITES IN MONONUCLEAR CELLS IN VITRO. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2008;7(4):203-208. Available from: https://sid.ir/paper/291223/en

    IEEE: Copy

    SH. NIKOU, M. BOZORGMEHR, H. NAMDAR AHMADABAD, ZOHEYR MOHAMMAD HASAN, S.M. MOAZENI, Z. POURPAK, and T. GHAZANFARI, “THE 14KDA PROTEIN MOLECULE ISOLATED FROM GARLIC SUPPRESSES INDOLEAMINE 2, 3- DIOXYGENASE METABOLITES IN MONONUCLEAR CELLS IN VITRO,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 7, no. 4, pp. 203–208, 2008, [Online]. Available: https://sid.ir/paper/291223/en

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