EVALUATION OF THE EFFECT OF IL-22 ON HUMAN CORD BLOOD CD4+ T CELLS

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ARASTEH J.; POURPAK Z.; EBTEKAR M.; POURFATH ELAH A.A.; MOHAMMAD HASAN ZOHEYR; FARAHMANDIAN T.; MAHMOUDZADEH NIKNAM H.

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2010 | Volume:9 | Issue:2 Page(s): 59-67

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Title

EVALUATION OF THE EFFECT OF IL-22 ON HUMAN CORD BLOOD CD4+ T CELLS

Author(s)

Keywords

CORD BLOOD

FOXP3

IL-22

REGULATORY T CELLS

Abstract

IL-22 is a member of IL-10 cytokine family which is believed to play an important role in inflammatory responses. IL-22 has similarities with IL-10 including conserved sequences with IL-10. IL-22 receptor is also comprised of two chains known as L-22R1 and L-10R2; supporting the speculation that the two cytokines may have similar effects.The aim of this study was to shed some light on the biological activity of IL-22 upon the CORD BLOOD CD4+CD25- T cells. In this research, CORD BLOOD T CD4+CD25- cells were cultured in presence of anti CD2/CD3/CD28 coated beads, IL-2 and IL-22 for two weeks at 37 oC and 5% CO2. Flow cytometry analysis showed that IL-22 has no effect upon CD25 and FOXP3 expression.Also, the results indicated that IL-22 is not involved in CD4+ T cell proliferation. Moreover, the results of suppression assay did not show any suppression effect on the cultured T cells. Thus, it seems that umbilical CORD BLOOD T cells probably do not express IL-22R1 on their surface.

Cites

THE EFFECT OF IL-22 AND IL-28 IN INDUCTION OF TYPE 1 REGULATORY T (TR1) CELLS

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APA: Copy

ARASTEH, J., POURPAK, Z., EBTEKAR, M., POURFATH ELAH, A.A., MOHAMMAD HASAN, ZOHEYR, FARAHMANDIAN, T., & MAHMOUDZADEH NIKNAM, H.. (2010). EVALUATION OF THE EFFECT OF IL-22 ON HUMAN CORD BLOOD CD4⁺ T CELLS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 9(2), 59-67. SID. https://sid.ir/paper/291243/en

Vancouver: Copy

ARASTEH J., POURPAK Z., EBTEKAR M., POURFATH ELAH A.A., MOHAMMAD HASAN ZOHEYR, FARAHMANDIAN T., MAHMOUDZADEH NIKNAM H.. EVALUATION OF THE EFFECT OF IL-22 ON HUMAN CORD BLOOD CD4⁺ T CELLS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2010;9(2):59-67. Available from: https://sid.ir/paper/291243/en

IEEE: Copy

J. ARASTEH, Z. POURPAK, M. EBTEKAR, A.A. POURFATH ELAH, ZOHEYR MOHAMMAD HASAN, T. FARAHMANDIAN, and H. MAHMOUDZADEH NIKNAM, “EVALUATION OF THE EFFECT OF IL-22 ON HUMAN CORD BLOOD CD4⁺ T CELLS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 9, no. 2, pp. 59–67, 2010, [Online]. Available: https://sid.ir/paper/291243/en

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