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Information Journal Paper

Title

THE EFFECT OF IL-22 AND IL-28 IN INDUCTION OF TYPE 1 REGULATORY T (TR1) CELLS

Pages

  158-167

Abstract

 Cytokines have been introduced as critical inducers in the development of Th subpopulations.Cytokines like IL-10 are involved in inducing regulatory T cells such as Type 1 regulatory T (Tr1) cells cells. IL-22 is a member of IL-10 family of cytokines, and IL-28A is a member of IFN-g family.In this study, CORD BLOOD mononuclear cells (CBMC) from normal healthy individuals were isolated by Ficoll and then naive T cells were purified by CD4+CD25+ Regulatory T cell Isolation kit. The effect of these two cytokines on production of IL-5, TGF-b, IL-10, IL-4 and IFN-g cytokines from CORD BLOOD T cells was investigated to identify TR1 CELLS as well as Th1 and Th2 POLARIZATION.Flow cytometric analysis showed that IL-28A and IL-22 were not effective in expression of IL-5 and TGF-b either alone or in synergy, but in view of IL-10, IL-4 and IFN-g, the results showed that IL-22 increased IL-10 and IL-4 but had a decreasing effect on IFN-g. The results showed that IL-28A was not effective in increasing or decreasing the level of IL-10, IL-4 and IFN-g.Therefore, according to these results, IL-22 and IL-28A were not effective in inducing TR1 CELLS.

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    Cite

    APA: Copy

    ARASTEH, JAVAD, EBTEKAR, MASSOUMEH, POURPAK, ZAHRA, POURFATHOLLAH, ALI AKBAR, MOHAMMAD HASSAN, ZUHAIR, KARDAR, GHOLAM ALI, ZARE, AHAD, SAGHAFI, SHIVA, & MOLLA HASSAN, AGHEEL TABAR. (2015). THE EFFECT OF IL-22 AND IL-28 IN INDUCTION OF TYPE 1 REGULATORY T (TR1) CELLS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(2), 158-167. SID. https://sid.ir/paper/291431/en

    Vancouver: Copy

    ARASTEH JAVAD, EBTEKAR MASSOUMEH, POURPAK ZAHRA, POURFATHOLLAH ALI AKBAR, MOHAMMAD HASSAN ZUHAIR, KARDAR GHOLAM ALI, ZARE AHAD, SAGHAFI SHIVA, MOLLA HASSAN AGHEEL TABAR. THE EFFECT OF IL-22 AND IL-28 IN INDUCTION OF TYPE 1 REGULATORY T (TR1) CELLS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(2):158-167. Available from: https://sid.ir/paper/291431/en

    IEEE: Copy

    JAVAD ARASTEH, MASSOUMEH EBTEKAR, ZAHRA POURPAK, ALI AKBAR POURFATHOLLAH, ZUHAIR MOHAMMAD HASSAN, GHOLAM ALI KARDAR, AHAD ZARE, SHIVA SAGHAFI, and AGHEEL TABAR MOLLA HASSAN, “THE EFFECT OF IL-22 AND IL-28 IN INDUCTION OF TYPE 1 REGULATORY T (TR1) CELLS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 2, pp. 158–167, 2015, [Online]. Available: https://sid.ir/paper/291431/en

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