β-ARRESTIN2 STIMULATES INTERLEUKIN-17 PRODUCTION AND EXPRESSION OF CD4+ T LYMPHOCYTES IN A MURINE ASTHMA MODEL

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LIU YI; WANG GU YI; LIU SHAO KUN; YANG MU YI; MA LI BING; LI KENG; GONG SU BO; ZHANG LI; CHEN PING; XIANG XU DONG

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2011 | Volume:10 | Issue:3 Page(s): 171-182

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Title

β-ARRESTIN2 STIMULATES INTERLEUKIN-17 PRODUCTION AND EXPRESSION OF CD4+ T LYMPHOCYTES IN A MURINE ASTHMA MODEL

Author(s)

Keywords

ASTHMA

β-ARRESTIN2

OF CD4+ T LYMPHOCYTES

EXTRACELLULAR SIGNAL-REGULATED KINASE 1/2

INTERLEUKIN-17

Abstract

Allergic ASTHMA is a complex and chronic inflammatory airway disease. INTERLEUKIN-17 is a pro-inflammatory cytokine which plays critical role in the pathogenesis of allergic ASTHMA. It has been reported that b-arrestin2 regulated the development of allergic ASTHMA at a proximal step in the inflammatory cascade. In this study, the influence of b-arrestin2 on INTERLEUKIN-17 production and expression of CD4+T lymphocytes in a murine ASTHMA model was investigated.Splenic CD4+T lymphocytes from wild-type mice and those from a murine ASTHMA model were purified. CD4+T lymphocytes from a murine ASTHMA model were transfected with siRNAs targeting the b-arrestin2 or were pretreated with the ERK1/2 inhibitor, PD98059. After stimulation, the protein expression of b-arrestin2 phosphorylated- ERK1/2 and IL-17 were detection by Western blot, the mRNA expression of IL-17 were detected by real-time PCR, the accumulation of IL-17 in supernatants were detected by ELISA.We found that b-arrestin2 phosphorylated-ERK1/2 and IL-17 expression in CD4+T lymphocytes from a murine ASTHMA model was increased compared with those from wildtype mice (p<0.01). Treatment of CD4+T lymphocytes with siRNAs targeting the b-arrestin2 down-regulated phosphorylated- ERK 1/2 and IL-17 expression (p<0.01). PD98059 decreased IL-17 production and expression in CD4+T lymphocytes in a murine ASTHMA model (p<0.05).We conclude that b-arrestin2 stimulated IL-17 production and expression of CD4+T lymphocytes in a murine ASTHMA model. The effect was partly mediated by ERK 1/2 activation. Targeting b-arrestin2 biological activity could be a valid therapeutic approach for the treatment of allergic ASTHMA.

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APA: Copy

LIU, YI, WANG, GU YI, LIU, SHAO KUN, YANG, MU YI, MA, LI BING, LI, KENG, GONG, SU BO, ZHANG, LI, CHEN, PING, & XIANG, XU DONG. (2011). β-ARRESTIN2 STIMULATES INTERLEUKIN-17 PRODUCTION AND EXPRESSION OF CD4⁺ T LYMPHOCYTES IN A MURINE ASTHMA MODEL. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 10(3), 171-182. SID. https://sid.ir/paper/291291/en

Vancouver: Copy

LIU YI, WANG GU YI, LIU SHAO KUN, YANG MU YI, MA LI BING, LI KENG, GONG SU BO, ZHANG LI, CHEN PING, XIANG XU DONG. β-ARRESTIN2 STIMULATES INTERLEUKIN-17 PRODUCTION AND EXPRESSION OF CD4⁺ T LYMPHOCYTES IN A MURINE ASTHMA MODEL. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2011;10(3):171-182. Available from: https://sid.ir/paper/291291/en

IEEE: Copy

YI LIU, GU YI WANG, SHAO KUN LIU, MU YI YANG, LI BING MA, KENG LI, SU BO GONG, LI ZHANG, PING CHEN, and XU DONG XIANG, “β-ARRESTIN2 STIMULATES INTERLEUKIN-17 PRODUCTION AND EXPRESSION OF CD4⁺ T LYMPHOCYTES IN A MURINE ASTHMA MODEL,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 10, no. 3, pp. 171–182, 2011, [Online]. Available: https://sid.ir/paper/291291/en

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