THE ACCURACY OF SERUM GALACTOMANNAN ASSAY IN DIAGNOSING INVASIVE PULMONARY ASPERGILLOSIS

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SARRAFZADEH SHOKOOH AZAM; HOSEINPOOR RAFATI ALI; ARDALAN MARYAM; MANSOURI DAVOOD; TABARSI PAYAM; POURPAK ZAHRA

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2010 | Volume:9 | Issue:3 Page(s): 149-155

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Title

THE ACCURACY OF SERUM GALACTOMANNAN ASSAY IN DIAGNOSING INVASIVE PULMONARY ASPERGILLOSIS

Author(s)

Keywords

INVASIVE PULMONARY ASPERGILLOSIS

IMMUNOCOMPROMISED

SERUM GALACTOMANNAN

Abstract

Galactomannan (GM) antigen is an aspergillus specific antigen that is released during the growth phase of invasive aspergillosis. We aimed to find the optimum cut-off and accuracy of SERUM GALACTOMANNAN assay in IMMUNOCOMPROMISED patients.Immunocompromised patients diagnosed with INVASIVE PULMONARY ASPERGILLOSIS (IPA) based on the European Organization for Research and Treatment of Cancer/Invasive Mycosis Study Group (EORTC/MSG) with three levels of certainty proven, probable and possible, referred for GM antigen measurement at Immunology, Asthma and Allergy Research Institute (IAARI) from 2006 to 2009 and if they met the criteria were enrolled in this study.Totally 49 patients with IPA were enrolled in our study. According to EORTC/MSG, patients categorized into three levels of certainty: They were diagnosed as ‘proven’ INVASIVE PULMONARY ASPERGILLOSIS 16 (32.7%), ‘probable’ 18 (36.7%) and ‘possible’ 15 (30.6%). The most common host risk factor was solid tumors 17 (34.7%). The accuracy of Galactomannan assay increased from 0.5 to 2 cut-offs. The optimum sensitivity and specificity obtained at the index cut-off of: ³1.5 for diagnosis of “proven” IPA; which were respectively, 69.2% and 72.2%.Other cut-offs had high variance between sensitivity and specificity for diagnosis of IPA.The calculated cut-off gained by receiver operating characteristic (ROC) analysis for detecting proven IPA was 1.5. Intermediate accuracy of serum GM test in conjunct with clinical findings would help early IPA detection among IMMUNOCOMPROMISED patients.

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APA: Copy

SARRAFZADEH, SHOKOOH AZAM, HOSEINPOOR RAFATI, ALI, ARDALAN, MARYAM, MANSOURI, DAVOOD, TABARSI, PAYAM, & POURPAK, ZAHRA. (2010). THE ACCURACY OF SERUM GALACTOMANNAN ASSAY IN DIAGNOSING INVASIVE PULMONARY ASPERGILLOSIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 9(3), 149-155. SID. https://sid.ir/paper/291310/en

Vancouver: Copy

SARRAFZADEH SHOKOOH AZAM, HOSEINPOOR RAFATI ALI, ARDALAN MARYAM, MANSOURI DAVOOD, TABARSI PAYAM, POURPAK ZAHRA. THE ACCURACY OF SERUM GALACTOMANNAN ASSAY IN DIAGNOSING INVASIVE PULMONARY ASPERGILLOSIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2010;9(3):149-155. Available from: https://sid.ir/paper/291310/en

IEEE: Copy

SHOKOOH AZAM SARRAFZADEH, ALI HOSEINPOOR RAFATI, MARYAM ARDALAN, DAVOOD MANSOURI, PAYAM TABARSI, and ZAHRA POURPAK, “THE ACCURACY OF SERUM GALACTOMANNAN ASSAY IN DIAGNOSING INVASIVE PULMONARY ASPERGILLOSIS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 9, no. 3, pp. 149–155, 2010, [Online]. Available: https://sid.ir/paper/291310/en

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