GENE POLYMORPHISMS OF 22 CYTOKINES IN MACEDONIAN CHILDREN WITH ATOPIC DERMATITIS

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STAVRIC KATARINA; PEOVA SONJA; TRAJKOV DEJAN; SPIROSKI MIRKO

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2012 | Volume:11 | Issue:1 Page(s): 37-50

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Title

GENE POLYMORPHISMS OF 22 CYTOKINES IN MACEDONIAN CHILDREN WITH ATOPIC DERMATITIS

Author(s)

STAVRIC KATARINA | PEOVA SONJA | TRAJKOV DEJAN | SPIROSKI MIRKO | Issue Writer Certificate

Keywords

ATOPIC DERMATITIS

CYTOKINE GENE POLYMORPHISMS

MACEDONIAN POPULATION

SSP GENOTYPING

Abstract

ATOPIC DERMATITIS (AD) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of T-helper 2 cells. The aim if this study was to determine whether CYTOKINE GENE POLYMORPHISMS might influence the development of AD. Single nucleotide polymorphisms in the genes for I-L1alpha, IL-1beta, IL-1R, IL-2, IL-4, IL-6, IL-10, IL-12, TGF beta, TNF and IFNgamma were investigated by PCR and sequence specific primers in Macedonian patients with AD (67 children, age of 6 months to 5 years) and 301 normal unrelated individuals. Susceptible cytokine polymorphisms for AD for eleven genotypes (IL-4 -33/T: T IL-4 -1098/G: G, TGFbeta cdn25C: G, IL-4 -1098/T: T, IL- 1alpha-889/C: T, IL-2+166/T: T, IL-1beta -511/C: T, IL-12 -1188/C: T, IL-10 -1082/A: G, IL- 1beta +3962/C: T, IFNgamma+874/A: T), five diplotypes, six haplotypes, and for alleles were found.Protective cytokine polymorphisms for AD for seven cytokine genotypes (IL-4- 1098/G: T, TGFbeta cdn25/G: G, IL-4 -33/C: C, IL-1alpha -889/C: C, IFNgamma+874/A: A, IL-10-1082/A: A, IL-1beta -511/C: C), one cytokine diplotypes, two cytokine haplotypes, and four cytokine alleles were also found. We concluded that several cytokine polymorphisms are protective, or susceptible associated with AD in population of Macedonians.

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APA: Copy

STAVRIC, KATARINA, TRAJKOV, DEJAN, SPIROSKI, MIRKO, & PEOVA, SONJA. (2012). GENE POLYMORPHISMS OF 22 CYTOKINES IN MACEDONIAN CHILDREN WITH ATOPIC DERMATITIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 11(1), 37-50. SID. https://sid.ir/paper/291329/en

Vancouver: Copy

STAVRIC KATARINA, TRAJKOV DEJAN, SPIROSKI MIRKO, PEOVA SONJA. GENE POLYMORPHISMS OF 22 CYTOKINES IN MACEDONIAN CHILDREN WITH ATOPIC DERMATITIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2012;11(1):37-50. Available from: https://sid.ir/paper/291329/en

IEEE: Copy

KATARINA STAVRIC, DEJAN TRAJKOV, MIRKO SPIROSKI, and SONJA PEOVA, “GENE POLYMORPHISMS OF 22 CYTOKINES IN MACEDONIAN CHILDREN WITH ATOPIC DERMATITIS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 11, no. 1, pp. 37–50, 2012, [Online]. Available: https://sid.ir/paper/291329/en

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