IMMUNOMODULATORY EFFECTS OF ASTRAGALUS GYPSICOLUS HYDROALCOHOLIC EXTRACT IN OVALBUMIN-INDUCED ALLERGIC MICE MODEL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHAFOURIAN BOROUJERDNIA MEHRI; AZEMI MOHAMMAD EBRAHIM; HEMMATI ALI ASGHAR; TAGHIAN AMIN; AZADMEHR ABBAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2011 | Volume:10 | Issue:4 Page(s): 281-288

Download Full-Text

View:

331

Download:

149

Cites:

Information Journal Paper

Title

IMMUNOMODULATORY EFFECTS OF ASTRAGALUS GYPSICOLUS HYDROALCOHOLIC EXTRACT IN OVALBUMIN-INDUCED ALLERGIC MICE MODEL

Author(s)

Keywords

ASTRAGALUS GYPSICOLUS

EXTRACT

ALLERGY

IL-4

IFNGUMMA

Abstract

Several studies have demonstrated that herbal EXTRACTs possess various biological effects including anti-inflammatory and anti-cancer activities. The present study was aimed to investigate the protective effects of theASTRAGALUS GYPSICOLUS (AG) hydroalcoholic EXTRACT in early allergic sensitized mice induced by ovalbumin.Phytochemical assay was used to recognize the main active constituents in the AG hydroalcoholic EXTRACT. Mice were immunized with subcutaneous injection of ovalbumin and aluminum hydroxide. Efficiency of sensitization was assessed by serum IgE levels and eosinophil count. After sensitization, two doses of EXTRACT (250 mg/kg and 500 mg/kg) were injected intrapritoneally.On day 14, mice were challenged with intrapritoneal injection of ovalbumin. IL-4 and IFNg levels in broncoalveolar lavage fluid, which had been collected on day 15, were assessed by Enzyme-Linked Immunosorbent Assay (ELISA) kit.Our results indicate two main active constituents including flavonoids and terpenoids are present in the AG hydroalcoholic EXTRACT. Intrapritoneal injection of the AG hydroalcoholic EXTRACT was able to decrease IL-4 and increase IFN2. It seems the AG hydroalcoholic EXTRACT has the potential to modulate the balance of Th1/Th2 cytokines in ALLERGY.

Cites

No record.

References

No record.

Cite

APA: Copy

GHAFOURIAN BOROUJERDNIA, MEHRI, AZEMI, MOHAMMAD EBRAHIM, HEMMATI, ALI ASGHAR, TAGHIAN, AMIN, & AZADMEHR, ABBAS. (2011). IMMUNOMODULATORY EFFECTS OF ASTRAGALUS GYPSICOLUS HYDROALCOHOLIC EXTRACT IN OVALBUMIN-INDUCED ALLERGIC MICE MODEL. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 10(4), 281-288. SID. https://sid.ir/paper/291333/en

Vancouver: Copy

GHAFOURIAN BOROUJERDNIA MEHRI, AZEMI MOHAMMAD EBRAHIM, HEMMATI ALI ASGHAR, TAGHIAN AMIN, AZADMEHR ABBAS. IMMUNOMODULATORY EFFECTS OF ASTRAGALUS GYPSICOLUS HYDROALCOHOLIC EXTRACT IN OVALBUMIN-INDUCED ALLERGIC MICE MODEL. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2011;10(4):281-288. Available from: https://sid.ir/paper/291333/en

IEEE: Copy

MEHRI GHAFOURIAN BOROUJERDNIA, MOHAMMAD EBRAHIM AZEMI, ALI ASGHAR HEMMATI, AMIN TAGHIAN, and ABBAS AZADMEHR, “IMMUNOMODULATORY EFFECTS OF ASTRAGALUS GYPSICOLUS HYDROALCOHOLIC EXTRACT IN OVALBUMIN-INDUCED ALLERGIC MICE MODEL,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 10, no. 4, pp. 281–288, 2011, [Online]. Available: https://sid.ir/paper/291333/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops