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1

Information Journal Paper

Title

LISTERIA MONOCYTOGENES PROTEIN FRACTION INDUCES DENDRITIC CELLS MATURATION AND T HELPER 1 IMMUNE RESPONSES

Pages

  1-10

Abstract

 Fully mature DENDRITIC CELLS (DCs) play pivotal role in inducing immune responses and converting naive T lymphocytes into functional Th1 cells. We aimed to evaluate LISTERIA MONOCYTOGENES-derived protein fractions to induce DC maturation and stimulating T helper (Th) 1 immune responses.In the present study, we fractionated LISTERIA MONOCYTOGENES-derived proteins by adding of ammonium sulfate in a stepwise manner. DCs were also generated from C57BL/6 mice bone marrow precursor cells. Then, the effects of protein fractions on bone marrow derived DC (BMDC) maturation were evaluated. In addition, we assessed the capacity of activated DCs to induce cytokine production and proliferation of lymphocytes.Listeria-derived protein fractions induced fully mature DCs expressing high costimulatory molecules such as CD80, CD86 and CD40. DCs that were activated by selected F3 fraction had low capacity to uptake exogenous antigens while secreted high levels of Interleukine (IL) -12. Moreover, lymphocytes cultured with activated BMDCs produced high amounts of IFN-g and showed higher proliferation than control. Listeria derived protein fractions differently influenced DC maturation.In conclusion, Listeria protein activated-BMDCs can be used as a cell based vaccine to induce anti-tumor immune responses.

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    APA: Copy

    SAEI, AZAD, BOGHOZIAN, ROOBINA, MIRZAEI, REZA, JAMALI, AREZOO, VAZIRI, BEHROOZ, & HADJATI, JAMSHID. (2014). LISTERIA MONOCYTOGENES PROTEIN FRACTION INDUCES DENDRITIC CELLS MATURATION AND T HELPER 1 IMMUNE RESPONSES. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(1), 1-10. SID. https://sid.ir/paper/291374/en

    Vancouver: Copy

    SAEI AZAD, BOGHOZIAN ROOBINA, MIRZAEI REZA, JAMALI AREZOO, VAZIRI BEHROOZ, HADJATI JAMSHID. LISTERIA MONOCYTOGENES PROTEIN FRACTION INDUCES DENDRITIC CELLS MATURATION AND T HELPER 1 IMMUNE RESPONSES. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(1):1-10. Available from: https://sid.ir/paper/291374/en

    IEEE: Copy

    AZAD SAEI, ROOBINA BOGHOZIAN, REZA MIRZAEI, AREZOO JAMALI, BEHROOZ VAZIRI, and JAMSHID HADJATI, “LISTERIA MONOCYTOGENES PROTEIN FRACTION INDUCES DENDRITIC CELLS MATURATION AND T HELPER 1 IMMUNE RESPONSES,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 1, pp. 1–10, 2014, [Online]. Available: https://sid.ir/paper/291374/en

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