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Information Journal Paper

Title

POLYMORPHISMS AND SERUM LEVEL OF MANNOSE-BINDING LECTIN: AN IRANIAN SURVEY

Pages

  428-432

Keywords

SINGLE NUCLEOTIDE POLYMORPHISM (SNP) 

Abstract

 Mannose-binding lectin (MBL) is a Ca+2 -dependent collagenous lectin, that is produced by liver and mediates innate immune responses by opsonization of pathogens. The serum level of MBL varies widely among healthy individuals, ranging from 0.05m g/ml (or lower) to over 5m g/ml, mainly depending on genetic variations.This study has examined promoter and exon 1 of mbl2 genotype among 117 Iranian healthy blood donors. MBL Single Nucleotide POLYMORPHISMS (SNPs) were genotyped using polymerase chain reaction (PCR), and serum levels of MBL were quantified using a double antibody enzyme linked immunosorbent assay (ELISA).Results of this study showed that there are two promoter POLYMORPHISMS at -550 (H/L variants) and -221 (Y/X variants) positions, and three POLYMORPHISMS in exon 1 at codon 52 (D Allele), 54 (B Allele), and 57 (C Allele) in this population. B allele was significantly correlated with the lowest serum MBL level. Our results also showed that the most frequent genotype was HYA/LXA, and the genotype that associated with the highest serum level of MBL was HYA/HYA. The genotype that causes lowest MBL production in Iranian population was LYB/LXA.These results showed some differences compared to that of the other populations. To verfiy the originality of these differences we may need to extend the study to a larger samples of respective populations; meanwhile the importance of a new mutation, nucleotide 101 of MBL2 exon1, reported in the current study should be taken in considerations in terms of its possible pathobiological effects in following studies.

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    APA: Copy

    SOLTANI, AHMAD, RAHMATIRAD, SARA, POURPAK, ZAHRA, ALIZADEH, ZAHRA, SAGHAFI, SHIVA, HAJIBEIGI, BASHIR, ZEIDI, MAJID, & FARAZMAND, ALI. (2014). POLYMORPHISMS AND SERUM LEVEL OF MANNOSE-BINDING LECTIN: AN IRANIAN SURVEY. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(6), 428-432. SID. https://sid.ir/paper/291388/en

    Vancouver: Copy

    SOLTANI AHMAD, RAHMATIRAD SARA, POURPAK ZAHRA, ALIZADEH ZAHRA, SAGHAFI SHIVA, HAJIBEIGI BASHIR, ZEIDI MAJID, FARAZMAND ALI. POLYMORPHISMS AND SERUM LEVEL OF MANNOSE-BINDING LECTIN: AN IRANIAN SURVEY. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(6):428-432. Available from: https://sid.ir/paper/291388/en

    IEEE: Copy

    AHMAD SOLTANI, SARA RAHMATIRAD, ZAHRA POURPAK, ZAHRA ALIZADEH, SHIVA SAGHAFI, BASHIR HAJIBEIGI, MAJID ZEIDI, and ALI FARAZMAND, “POLYMORPHISMS AND SERUM LEVEL OF MANNOSE-BINDING LECTIN: AN IRANIAN SURVEY,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 6, pp. 428–432, 2014, [Online]. Available: https://sid.ir/paper/291388/en

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