EVALUATION OF THE EFFECT OF ASCORBIC ACID ADMINISTRATION ON GENE EXPRESSION LEVEL OF IL-6 AND TNF-α CYTOKINES IN DECEASED DONORS

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KAZEMI MASOUMEH; TABEI SEYED MOHAMMAD BAGHER; NAJAFIZADEH KATAYOUN; MEHRABI SISAKHT JAFAR; MILANI SOHEYLA; KHOSRAVI MOHAMMAD BAGHER

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2015 | Volume:14 | Issue:2 Page(s): 149-157

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Title

EVALUATION OF THE EFFECT OF ASCORBIC ACID ADMINISTRATION ON GENE EXPRESSION LEVEL OF IL-6 AND TNF-α CYTOKINES IN DECEASED DONORS

Author(s)

Keywords

ANTIOXIDANTS

ASCORBIC ACID

BRAIN DEATH

CYTOKINES

INFLAMMATION

LIVER TRANSPLANTATION

Abstract

Brain death is associated with increased inflammatory CYTOKINES levels and poor graft quality to transplant. We aimed to evaluate the impact of ASCORBIC ACID (AA) on the inflammatory status of Brain-Dead Donors (BDDs).Forty BDDs were randomly divided into two groups. Donor treatment (n=20) consisted of 100 mg/kg AA infusion 6 hours before donor operation and subsequent infusion of 100 mg/kg/p6h until organ removal. Blood samples were taken at three times, 6 hours before donor surgery (TP1), immediately after laparotomy (TP2), and before organ removal (TP3). Gene expression level and serum concentration of IL-6 and TNF-a CYTOKINES were assessed by real-time PCR and ELISA methods. To investigate transplanted liver function, serum values of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), and Billirubin-Total were evaluated on the 1st, 3rd, and 10th postoperative days.We found a significant reduction in IL-6 mRNA expression ratio of TP3 to TP1 following AA application among BDDs. Despite the considerable decrease in treated donors regarding IL-6 mRNA expression ratio of TP2 to TP1, TP3 to TP2, and also TNF-a variations in these periods, the results were not significant. Regarding serum concentration of these CYTOKINES, particularly IL-6, there was a decrease between TP2 and TP3 following AA application in the treated donors. Furthermore, a significant reduction was found in serum AST and ALT levels in the recipients of treated group on the 3rd day compared to the 1st day after transplantation.It seems that AA beneficially affects the inflammatory status of BDDs, resulting in improved primary allograft function.

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References

ASSOCIATION OF INCREASED PLASMA INTERLEUKIN-6 AND TNF-α LEVELS IN DONORS WITH THE COMPLICATION RATES IN LIVER TRANSPLANT RECIPIENTS

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APA: Copy

KAZEMI, MASOUMEH, TABEI, SEYED MOHAMMAD BAGHER, NAJAFIZADEH, KATAYOUN, MEHRABI SISAKHT, JAFAR, MILANI, SOHEYLA, & KHOSRAVI, MOHAMMAD BAGHER. (2015). EVALUATION OF THE EFFECT OF ASCORBIC ACID ADMINISTRATION ON GENE EXPRESSION LEVEL OF IL-6 AND TNF-α CYTOKINES IN DECEASED DONORS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(2), 149-157. SID. https://sid.ir/paper/291426/en

Vancouver: Copy

KAZEMI MASOUMEH, TABEI SEYED MOHAMMAD BAGHER, NAJAFIZADEH KATAYOUN, MEHRABI SISAKHT JAFAR, MILANI SOHEYLA, KHOSRAVI MOHAMMAD BAGHER. EVALUATION OF THE EFFECT OF ASCORBIC ACID ADMINISTRATION ON GENE EXPRESSION LEVEL OF IL-6 AND TNF-α CYTOKINES IN DECEASED DONORS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(2):149-157. Available from: https://sid.ir/paper/291426/en

IEEE: Copy

MASOUMEH KAZEMI, SEYED MOHAMMAD BAGHER TABEI, KATAYOUN NAJAFIZADEH, JAFAR MEHRABI SISAKHT, SOHEYLA MILANI, and MOHAMMAD BAGHER KHOSRAVI, “EVALUATION OF THE EFFECT OF ASCORBIC ACID ADMINISTRATION ON GENE EXPRESSION LEVEL OF IL-6 AND TNF-α CYTOKINES IN DECEASED DONORS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 2, pp. 149–157, 2015, [Online]. Available: https://sid.ir/paper/291426/en

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