مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION BETWEEN PEPTIDYLARGININE DEIMINASE TYPE 4 RS1748033 POLYMORPHISM AND SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IN ZAHEDAN, SOUTHEAST IRAN

Pages

  255-260

Abstract

 There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene POLYMORPHISMs and risk of RHEUMATOID ARTHRITIS (RA). The aim of the present study was to investigate the impact of PADI4 rs1748033 POLYMORPHISM and susceptibility to RA in a sample of the Iranian population.This case-control study was done on 150 patients with RA and 150 healthy subjects. PADI4 rs1748033 genotyping was done using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) assay.The PADI4 rs1748033 variant increased the risk of RA in codominant (OR=1.67, 95%CI=1.03-2.71, p=0.048, CT vs CC; OR=2.73, 95%CI=1.25-5.97, p=0.013, TT vs CC) and dominant (OR=1.84, 95%CI=1.15-2.92, p=0.014, CT+TT vs CC) tested inheritance models. In addition, the PADI4 rs1748033 T allele increased the risk of RA (OR=1.63, 95%CI=1.16-2.29, p=0.006) in comparison with C allele.In conclusion, our finding indicated that PADI4 rs1748033 gene POLYMORPHISM increased the risk of RA in a sample of the Iranian population.

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    APA: Copy

    HASHEMI, MOHAMMAD, ZAKERI, ZAHRA, taheri, hamed, BAHARI, GHOLAMREZA, & TAHERI, MOHSEN. (2015). ASSOCIATION BETWEEN PEPTIDYLARGININE DEIMINASE TYPE 4 RS1748033 POLYMORPHISM AND SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IN ZAHEDAN, SOUTHEAST IRAN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(3), 255-260. SID. https://sid.ir/paper/291439/en

    Vancouver: Copy

    HASHEMI MOHAMMAD, ZAKERI ZAHRA, taheri hamed, BAHARI GHOLAMREZA, TAHERI MOHSEN. ASSOCIATION BETWEEN PEPTIDYLARGININE DEIMINASE TYPE 4 RS1748033 POLYMORPHISM AND SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IN ZAHEDAN, SOUTHEAST IRAN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(3):255-260. Available from: https://sid.ir/paper/291439/en

    IEEE: Copy

    MOHAMMAD HASHEMI, ZAHRA ZAKERI, hamed taheri, GHOLAMREZA BAHARI, and MOHSEN TAHERI, “ASSOCIATION BETWEEN PEPTIDYLARGININE DEIMINASE TYPE 4 RS1748033 POLYMORPHISM AND SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IN ZAHEDAN, SOUTHEAST IRAN,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 3, pp. 255–260, 2015, [Online]. Available: https://sid.ir/paper/291439/en

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