EVALUATION OF SOLUBLE HUMAN LEUKOCYTE ANTIGEN-G (SHLA-G) ISOFORMS AND REGULATORY T CELLS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS

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ALSAHEBFOSOUL FERESHTEH; ZAVARAN HOSSEINI AHMAD; SALEHI RASOUL; ETEMADIFAR MASOOD; ESMAEIL NAFISEH; JAMSHIDIAN AZAM

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2015 | Volume:14 | Issue:3 Page(s): 298-305

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Title

EVALUATION OF SOLUBLE HUMAN LEUKOCYTE ANTIGEN-G (SHLA-G) ISOFORMS AND REGULATORY T CELLS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS

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Keywords

MULTIPLE SCLEROSIS

REGULATORY T CELLS

SHLA-G

Abstract

Soluble forms of nonclassical human leukocyte antigen (HLA)-G have recently been suggested as immunomodulatory factors in MULTIPLE SCLEROSIS (MS). HLA-G inhibits the effecter function of T cells and natural killer (NK) cells. Also REGULATORY T CELLS (Treg) are considered as pivotal players in MS pathogenesis. Thus, we aimed to evaluate the presence of HLA-G molecules and Treg cells in Relapsing-Remitting MULTIPLE SCLEROSIS (RRMS) patients and compare it to healthy controls.Patients with RRMS (n=205, mean age=31.32±8.53) and healthy subjects (n=205, mean age=32.2±7.48) were studied. The patients subgrouped to untreated and treated with Interferon beta. Then SHLA-G levels (sHLA-G1 and SHLA-G5) were measured using ELISA method. Treg (CD4+CD25+ Foxp3+) cells in patients who had SHLA-G>10 U/ml were characterized by using flow cytometry.Our data showed that there was no significant differences between RRMS patients and healthy controls in SHLA-G concentration (p>0.05). Treg cell frequencies were higher in the patients who had SHLA-G >10 U/ml compared to healthy subjects (p<0.05).Collectively, there was significant correlation between SHLA-G and frequency of Treg cells in treated RRMS patients and healthy individuals. It seems that high level SHLA-G has been instrumental in raising frequency of Treg cells in treated patients and could be associated with remission of MS disease.

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APA: Copy

ALSAHEBFOSOUL, FERESHTEH, ZAVARAN HOSSEINI, AHMAD, SALEHI, RASOUL, ETEMADIFAR, MASOOD, ESMAEIL, NAFISEH, & JAMSHIDIAN, AZAM. (2015). EVALUATION OF SOLUBLE HUMAN LEUKOCYTE ANTIGEN-G (SHLA-G) ISOFORMS AND REGULATORY T CELLS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(3), 298-305. SID. https://sid.ir/paper/291450/en

Vancouver: Copy

ALSAHEBFOSOUL FERESHTEH, ZAVARAN HOSSEINI AHMAD, SALEHI RASOUL, ETEMADIFAR MASOOD, ESMAEIL NAFISEH, JAMSHIDIAN AZAM. EVALUATION OF SOLUBLE HUMAN LEUKOCYTE ANTIGEN-G (SHLA-G) ISOFORMS AND REGULATORY T CELLS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(3):298-305. Available from: https://sid.ir/paper/291450/en

IEEE: Copy

FERESHTEH ALSAHEBFOSOUL, AHMAD ZAVARAN HOSSEINI, RASOUL SALEHI, MASOOD ETEMADIFAR, NAFISEH ESMAEIL, and AZAM JAMSHIDIAN, “EVALUATION OF SOLUBLE HUMAN LEUKOCYTE ANTIGEN-G (SHLA-G) ISOFORMS AND REGULATORY T CELLS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 3, pp. 298–305, 2015, [Online]. Available: https://sid.ir/paper/291450/en

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