Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein

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Ghorbani Mohammad Mehdi; FARAZMANDFAR TOURAJ; Nasirikenari Mehrab; ABEDIANKENARI SAEID; MEMARIAN ALI; SHAHBAZI MAJID

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:3 Page(s): 300-309

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Title

Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein

Author(s)

Keywords

Demyelination

Experimental autoimmune encephalomyelitis

Inflammation

Interleukin 17

Multiple sclerosis

Abstract

Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. MS creates a wide range of symptoms with lifelong debilitating consequences. The hallmark of the disease is the Inflammation of the nervous system, which can lead to damage to the nerve tissue and loss of function of the neurons. IL-17 has a prominent role in the beginning of inflammatory reactions. Here, we analyzed a mouse model developed using anti-myelin antibodies. This mouse model mimics many symptoms of MS in humans. C57BL/6 mice were randomly divided into five groups. Mice were immunized subcutaneously with 50 μ g, 100 μ g, 150 μ g and 200 μ g myelin oligodendrocyte glycoprotein in complete Freund’ s adjuvant containing 4 mg/Ml Mycobacterium tuberculosis and two injections of 800 ng of pertussis toxin intraperitoneally, on day 0 and 2 post immunization. Serum level of IL-17 was measured, Inflammation and Demyelination of brain tissue were also evaluated. Mice with Experimental autoimmune encephalomyelitis demonstrated inflammatory cell accumulation, different degrees of Demyelination in the brain, and rising levels of serum IL-17 depending on the dose of the anti-myelin antibody. Our study demonstrates that level of IL-17 production is directly associated with Inflammation and Demyelination. In addition, different degrees of Experimental autoimmune encephalomyelitis in mice can be utilized to test a wide range of therapeutic interventions for MS treatment.

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APA: Copy

Ghorbani, Mohammad Mehdi, FARAZMANDFAR, TOURAJ, Nasirikenari, Mehrab, ABEDIANKENARI, SAEID, MEMARIAN, ALI, & SHAHBAZI, MAJID. (2019). Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(3), 300-309. SID. https://sid.ir/paper/291571/en

Vancouver: Copy

Ghorbani Mohammad Mehdi, FARAZMANDFAR TOURAJ, Nasirikenari Mehrab, ABEDIANKENARI SAEID, MEMARIAN ALI, SHAHBAZI MAJID. Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(3):300-309. Available from: https://sid.ir/paper/291571/en

IEEE: Copy

Mohammad Mehdi Ghorbani, TOURAJ FARAZMANDFAR, Mehrab Nasirikenari, SAEID ABEDIANKENARI, ALI MEMARIAN, and MAJID SHAHBAZI, “Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 3, pp. 300–309, 2019, [Online]. Available: https://sid.ir/paper/291571/en

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