Ovariectomy Modifies TH2, and TH17 Balance in BALB/C Allergic Mice

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Almeida Souza Marcos Paulo; da Silva Lima Fernanda Macedo; Muniz Igor Pereira; Pereira italo Sousa; de Oliveira Sousa Larissa Rodrigues; Leite Galantini Maria Poliana; dos Santos Denisar Palmito; Figueiredo Tiana Baqueiro; Augusto da Silva Robson Amaro

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2017 | Volume:16 | Issue:6 Page(s): 522-536

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Title

Ovariectomy Modifies TH2, and TH17 Balance in BALB/C Allergic Mice

Author(s)

Keywords

Airway inflammation

Asthma

IL-17A

Ovariectomy

Sex hormones

Abstract

Asthma is a chronic inflammation of the airways affecting over 300 million people worldwide. As in the autoimmune diseases, it is well described that women are the most affected by Asthma. The higher number of women presenting this pathology suggests the involvement of female Sex hormones in the construction of the allergic immune response. Female Balb/c mice were used for the experiments. Thirty-eight animals were separated into four groups: OVX-Ova; Sham-Ova; OVX-Sal; Sham-Sal. Then animals underwent acute allergic induction protocol by Ovalbulmin (OVA). Ovariectomized animals showed greater number of leukocytes in bronchoalveolar lavage (BAL) and elevated white blood cells recruitment to the lung environment observed by histological analysis. There was a significant increase of eosinophils and mast cells in inflammatory sites at pulmonary tissue. The relative uterine and body weight were lower in ovariectomized animals and higher in Sham mice, respectively. Moreover, the lack of the Sex hormones induced an increase in interleukin (IL)-4 and titers of immunoglobulin G1 (IgG1) antibodies. However, increased production of IL-17A was only observed in Sham animals. Altogether, data this study suggest that Ovariectomy induces the formation of a stronger Th2 response in allergic animal. However, the immune processes involved in the allergic response in females currently remain unclear.

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APA: Copy

Almeida Souza, Marcos Paulo, da Silva Lima, Fernanda Macedo, Muniz, Igor Pereira, Pereira, italo Sousa, de Oliveira Sousa, Larissa Rodrigues, Leite Galantini, Maria Poliana, dos Santos, Denisar Palmito, Figueiredo, Tiana Baqueiro, & Augusto da Silva, Robson Amaro. (2017). Ovariectomy Modifies TH2, and TH17 Balance in BALB/C Allergic Mice. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 16(6), 522-536. SID. https://sid.ir/paper/291582/en

Vancouver: Copy

Almeida Souza Marcos Paulo, da Silva Lima Fernanda Macedo, Muniz Igor Pereira, Pereira italo Sousa, de Oliveira Sousa Larissa Rodrigues, Leite Galantini Maria Poliana, dos Santos Denisar Palmito, Figueiredo Tiana Baqueiro, Augusto da Silva Robson Amaro. Ovariectomy Modifies TH2, and TH17 Balance in BALB/C Allergic Mice. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2017;16(6):522-536. Available from: https://sid.ir/paper/291582/en

IEEE: Copy

Marcos Paulo Almeida Souza, Fernanda Macedo da Silva Lima, Igor Pereira Muniz, italo Sousa Pereira, Larissa Rodrigues de Oliveira Sousa, Maria Poliana Leite Galantini, Denisar Palmito dos Santos, Tiana Baqueiro Figueiredo, and Robson Amaro Augusto da Silva, “Ovariectomy Modifies TH2, and TH17 Balance in BALB/C Allergic Mice,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 16, no. 6, pp. 522–536, 2017, [Online]. Available: https://sid.ir/paper/291582/en

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