Effect of Periodontal Treatment on the Crevicular Level of High-mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients with Chronic Periodontitis

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PAKNEJAD MOJGAN; SATTARI MANDANA; AKBARI SOLMAZ; Mehrfar Ali; Aslroosta Hoori

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2017 | Volume:16 | Issue:6 Page(s): 554-560

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Title

Effect of Periodontal Treatment on the Crevicular Level of High-mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients with Chronic Periodontitis

Author(s)

Keywords

Chronic periodontitis

Gingival crevicular fluid

HMGB1 protein

TREM1 protein

Abstract

The present study aimed to compare the levels of high-mobility group box 1(HMGB1) and soluble triggering receptor expressed on myeloid cells (sTREM1) in the Gingival crevicular fluid (GCF). This cross-sectional cohort trial investigated two groups of 22 eligible Chronic periodontitis and 22 periodontally healthy individuals (student volunteers) both before and after the periodontal treatment. GCF was collected from the deepest pockets with clinical attachment loss≥ 3 mm. Both groups received oral hygiene instructions, and scaling and root planning were performed in the test group. Enzyme-linked immunosorbent assay kit (ELISA) was used to measure the levels of HMGB1 and sTREM1 in GCF samples collected before and 1 month after non-surgical periodontal treatment. The results showed that HMGB1 levels were significantly higher in the Chronic periodontitis patients than those of the healthy individuals before treatment (p<0. 02) and decreased significantly after periodontal treatment, which reduced gingival inflammation. Furthermore, the levels of sTREM1 marker were significantly higher in periodontitis patients before (p<0. 001) and 1 month after treatment than in healthy individuals (p<0. 003) although its crevicular levels decreased after periodontal therapy in periodontitis group. The higher levels of sTREM1 and HMGB1 cytokines in GCF of periodontitis patients and the significant decrease after the introduction of the periodontal treatment underlines the importance of HMGB1 and sTREM1 in pathogenesis of periodontitis.

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APA: Copy

PAKNEJAD, MOJGAN, SATTARI, MANDANA, AKBARI, SOLMAZ, Mehrfar, Ali, & Aslroosta, Hoori. (2017). Effect of Periodontal Treatment on the Crevicular Level of High-mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients with Chronic Periodontitis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 16(6), 554-560. SID. https://sid.ir/paper/291583/en

Vancouver: Copy

PAKNEJAD MOJGAN, SATTARI MANDANA, AKBARI SOLMAZ, Mehrfar Ali, Aslroosta Hoori. Effect of Periodontal Treatment on the Crevicular Level of High-mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients with Chronic Periodontitis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2017;16(6):554-560. Available from: https://sid.ir/paper/291583/en

IEEE: Copy

MOJGAN PAKNEJAD, MANDANA SATTARI, SOLMAZ AKBARI, Ali Mehrfar, and Hoori Aslroosta, “Effect of Periodontal Treatment on the Crevicular Level of High-mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients with Chronic Periodontitis,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 16, no. 6, pp. 554–560, 2017, [Online]. Available: https://sid.ir/paper/291583/en

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