Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HESAMPOUR FATEMEH; NAMAVAR JAHROMI BAHIA; Tahmasebi Foroozan; GHARESI FARD BEHROUZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:1 Page(s): 91-99

Download Full-Text

View:

210

Download:

156

Cites:

Information Journal Paper

Title

Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome

Author(s)

HESAMPOUR FATEMEH | NAMAVAR JAHROMI BAHIA | Tahmasebi Foroozan | GHARESI FARD BEHROUZ | Issue Writer Certificate

Keywords

Interleukin

17A;Interleukin

32;Polycystic ovary syndrome

Abstract

Polycystic ovary syndrome (PCOS) is correlated with low-grade chronic inflammation. Interleukin-17A (IL-17A) and Interleukin-32 (IL-32) are two members of the proinflammatory cytokines which act as significant components of the immune system during certain inflammatory diseases. Along with immunological processes, genetic factors play major roles in predisposition to PCOS. There are myriad single nucleotide polymorphisms (SNPs) within IL-17A and IL-32 genes that may affect their production and the susceptibility of individuals to PCOS. The objective of the present research was to investigate the association between IL-17A (rs2275913) and IL-32 (rs9927163, rs4786370) SNPs, and also their serum levels with susceptibility to PCOS in a group of Iranian women. In this case-control study, 150 PCOS patients (mean age of 29. 1 years) and 150 healthy women (mean age of 26. 1 years) were analyzed in terms of IL-17A and IL-32 SNPs via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Furthermore, serum levels of IL-17A and IL-32 cytokines were measured through the use of ELISA method. There were significant differences between PCOS and healthy women regarding IL-17A rs2275913 alleles, genotypes frequencies (p=0. 005, and 0. 01, respectively) and the allelic distribution of IL-32 rs9927163 SNP (p=0. 03). Additionally, significant differences were indicated between two groups concerning the AG genotype against AA+GG genotypes (p=0. 009) and the GG genotype against AA+AG genotypes (p=0. 006) in IL-17A rs2275913 SNP. In the matter of IL-32 gene SNPs, GC haplotype frequency was significantly different between patients and controls (p=0. 05). Furthermore, IL-32 serum level was not significantly different between the two studied groups and the serum level of IL-17A was not detectable. In conclusion, IL-17A and IL-32 SNPs might be associated with predisposition to PCOS in Iranian women.

Cites

No record.

References

Cite

APA: Copy

HESAMPOUR, FATEMEH, NAMAVAR JAHROMI, BAHIA, Tahmasebi, Foroozan, & GHARESI FARD, BEHROUZ. (2019). Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(1), 91-99. SID. https://sid.ir/paper/291593/en

Vancouver: Copy

HESAMPOUR FATEMEH, NAMAVAR JAHROMI BAHIA, Tahmasebi Foroozan, GHARESI FARD BEHROUZ. Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(1):91-99. Available from: https://sid.ir/paper/291593/en

IEEE: Copy

FATEMEH HESAMPOUR, BAHIA NAMAVAR JAHROMI, Foroozan Tahmasebi, and BEHROUZ GHARESI FARD, “Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 1, pp. 91–99, 2019, [Online]. Available: https://sid.ir/paper/291593/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops