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Information Journal Paper

Title

Immunomodulatory Effects of Human Adipose Tissue-derived Mesenchymal Stem Cells on T Cell Subsets in Patients with Rheumatoid Arthritis

Pages

  114-119

Abstract

 Adipose-derived mesenchymal stem cells (Ad-MSCs) have been reported to suppress the effector T cell responses and have beneficial effects on various immune disorders, like Rheumatoid arthritis (RA). This study was designed to investigate the effects of co-cultured Ad-MSCs on peripheral blood mononuclear cells (PBMCs) of RA patients and healthy individuals, through assessing transcription factors of T cell subsets. PBMCs from RA patients and healthy donors were co-cultured with Ad-MSCs with or without Phytohaemagglutinin (PHA). The quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression of T-box 21 (T-bet), GATA-binding protein-3 (GATA3), retinoid-related orphan receptor γ t (ROR-γ; t) and forkhead box P3 (Foxp3). Based on the results, Ad-MSCs greatly upregulated Th2 and Treg cell transcription factors, i. e., GATA3 and Foxp3 (p<0. 05), and downregulated Th1 and Th17 transcription factors, i. e., T-bet and RORγ t (p<0. 05). These results demonstrate that Ad-MSCs can result in an immunosuppressive environment through inhibition of pro-inflammatory T cells and induction of T cells with a regulatory phenotype. Therefore, they might have important clinical implications for inflammatory and autoimmune diseases such as RA.

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    APA: Copy

    BAHARLOU, RASOUL, RASHIDI, NESA, AHMADI VASMEHJANI, ABBAS, Khoubyari, Mahshid, SHEIKH, MARYAM, & Erfanian, Saiedeh. (2019). Immunomodulatory Effects of Human Adipose Tissue-derived Mesenchymal Stem Cells on T Cell Subsets in Patients with Rheumatoid Arthritis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(1), 114-119. SID. https://sid.ir/paper/291594/en

    Vancouver: Copy

    BAHARLOU RASOUL, RASHIDI NESA, AHMADI VASMEHJANI ABBAS, Khoubyari Mahshid, SHEIKH MARYAM, Erfanian Saiedeh. Immunomodulatory Effects of Human Adipose Tissue-derived Mesenchymal Stem Cells on T Cell Subsets in Patients with Rheumatoid Arthritis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(1):114-119. Available from: https://sid.ir/paper/291594/en

    IEEE: Copy

    RASOUL BAHARLOU, NESA RASHIDI, ABBAS AHMADI VASMEHJANI, Mahshid Khoubyari, MARYAM SHEIKH, and Saiedeh Erfanian, “Immunomodulatory Effects of Human Adipose Tissue-derived Mesenchymal Stem Cells on T Cell Subsets in Patients with Rheumatoid Arthritis,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 1, pp. 114–119, 2019, [Online]. Available: https://sid.ir/paper/291594/en

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