مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

271
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

134
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Regulatory Effects of Estradiol on Peripheral Blood Mononuclear Cells Activation in Patients with Asthma

Pages

  9-17

Abstract

 Asthma prevalence and severity are greater in women than in men, and mounting evidence suggests this is in part related to female steroid sex hormones. Conflicting data are reported regarding pro-and anti-inflammatory properties of Estradiol. This study was designed to clarify whether Estradiol may contribute to enhanced T helper (Th) 17-associated cytokines production by peripheral blood mononuclear cells (PBMC) in Asthmatic patients and healthy individuals. PBMCs from patients with Asthma and healthy donors were cultured with 17-β Estradiol (E2) and phytohemagglutinin (PHA). The quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure IL-6, IL-17, IL-23 and TGF-β; . We observed a significant increased IL-17, IL-23 and TGF-β; expression in PBMCs of patients compared to the healthy individuals. In addition, our findings indicated that IL-6 and IL-17 expressions in PBMCs were induced, following E2 treatment. Our results identified an impact of E2 in stimulation of Th17 phenotype, and upon hormonal oscillations and hormone replacement therapy (HRT), Asthma inflammation may be mediated by Th17-associated cytokines.

Cites

References

  • No record.

    • Cite

    APA: Copy

    AHMADI VASMEHJANI, ABBAS, BAHARLOU, RASOUL, ATASHZAR, MOHAMMAD REZA, Raofi, Rahim, JAFARI, MOHAMMAD, & Razavi, Faezeh Sadat. (2018). Regulatory Effects of Estradiol on Peripheral Blood Mononuclear Cells Activation in Patients with Asthma. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 17(1), 9-17. SID. https://sid.ir/paper/291616/en

    Vancouver: Copy

    AHMADI VASMEHJANI ABBAS, BAHARLOU RASOUL, ATASHZAR MOHAMMAD REZA, Raofi Rahim, JAFARI MOHAMMAD, Razavi Faezeh Sadat. Regulatory Effects of Estradiol on Peripheral Blood Mononuclear Cells Activation in Patients with Asthma. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2018;17(1):9-17. Available from: https://sid.ir/paper/291616/en

    IEEE: Copy

    ABBAS AHMADI VASMEHJANI, RASOUL BAHARLOU, MOHAMMAD REZA ATASHZAR, Rahim Raofi, MOHAMMAD JAFARI, and Faezeh Sadat Razavi, “Regulatory Effects of Estradiol on Peripheral Blood Mononuclear Cells Activation in Patients with Asthma,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 17, no. 1, pp. 9–17, 2018, [Online]. Available: https://sid.ir/paper/291616/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button