The Anti-tumoral Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID on Treg Cells Frequency and MMP-2, MMP-9, CCL22 and TGFβ 1 Gene Expression in Pre-surgical Breast Cancer Patients

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Kashefi Sarvenaz; AHMADI HAMID; OMRANIPOUR RAMESH; MAHMOODZADEH HABIBOLLAH; Jafarnezhad Ansariha Fahimeh; TOFIGHI ZAVAREH FARZANEH; MIRSHAFIEY ABBAS

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:1 Page(s): 80-90

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Title

The Anti-tumoral Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID on Treg Cells Frequency and MMP-2, MMP-9, CCL22 and TGFβ 1 Gene Expression in Pre-surgical Breast Cancer Patients

Author(s)

Keywords

Breast Cancer

-D-Mannuronic acid

Chemopreventive

M2000

Nonsteroidal anti-inflammatory drug

Abstract

With respect to the role of chronic inflammation in the induction and progression of Breast Cancer (BC). The relationship between tumor and tumor microenvironment may be a hopeful strategy for BC therapy. According to the effect of β;-D-Mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory drug (NSAID) on BC murine model and 4T1 cell line, we started to study that was a phase II, randomized, controlled clinical trial. 24 women with BC were included in this study and were followed by fixed oral doses of M2000, 500 mg two times a day (6-8 weeks). Blood samples were collected at baseline and weeks 6-8. To compare the patterns of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), C-C motif chemokine ligand 22 (CCL22) and The transforming growth factor-beta 1 (TGFβ; 1) gene expression and T regulatory cells (Tregs) frequency of healthy women normal controls with BC patients, a set of 10 blood samples of women healthy volunteers was collected. The gene expression was evaluated by quantitative Real-time PCR (qRT-PCR) and the frequency of Tregs was assessed by flow cytometry. Our results showed, reduction in MMP-2 (p=0. 08), MMP-9 (p=0. 03), CCL22 (p=0. 003) and TGFβ; 1 (p=0. 1) gene expression and Tregs frequency (p=0. 01) which play a main role in the development of chronic inflammation, angiogenesis, tumorigenesis and metastasis. Our findings demonstrated that M2000 therapy as a novel designed NSAID had valuable therapeutic effects on BC. No adverse effects were observed following the use of M2000 after 6-8 weeks.

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APA: Copy

Kashefi, Sarvenaz, AHMADI, HAMID, OMRANIPOUR, RAMESH, MAHMOODZADEH, HABIBOLLAH, Jafarnezhad Ansariha, Fahimeh, TOFIGHI ZAVAREH, FARZANEH, & MIRSHAFIEY, ABBAS. (2019). The Anti-tumoral Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID on Treg Cells Frequency and MMP-2, MMP-9, CCL22 and TGFβ 1 Gene Expression in Pre-surgical Breast Cancer Patients. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(1), 80-90. SID. https://sid.ir/paper/291599/en

Vancouver: Copy

Kashefi Sarvenaz, AHMADI HAMID, OMRANIPOUR RAMESH, MAHMOODZADEH HABIBOLLAH, Jafarnezhad Ansariha Fahimeh, TOFIGHI ZAVAREH FARZANEH, MIRSHAFIEY ABBAS. The Anti-tumoral Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID on Treg Cells Frequency and MMP-2, MMP-9, CCL22 and TGFβ 1 Gene Expression in Pre-surgical Breast Cancer Patients. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(1):80-90. Available from: https://sid.ir/paper/291599/en

IEEE: Copy

Sarvenaz Kashefi, HAMID AHMADI, RAMESH OMRANIPOUR, HABIBOLLAH MAHMOODZADEH, Fahimeh Jafarnezhad Ansariha, FARZANEH TOFIGHI ZAVAREH, and ABBAS MIRSHAFIEY, “The Anti-tumoral Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID on Treg Cells Frequency and MMP-2, MMP-9, CCL22 and TGFβ 1 Gene Expression in Pre-surgical Breast Cancer Patients,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 1, pp. 80–90, 2019, [Online]. Available: https://sid.ir/paper/291599/en

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