Altered Frequencies of CD4+ CD25+ Foxp3+ and CD8+ CD25+ Foxp3+ Regulatory T Cells in Pre-eclampsia

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ZARE MARYAM; DOROUDCHI MEHRNOOSH; GHARESI FARD BEHROUZ

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2018 | Volume:17 | Issue:6 Page(s): 540-547

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Title

Altered Frequencies of CD4+ CD25+ Foxp3+ and CD8+ CD25+ Foxp3+ Regulatory T Cells in Pre-eclampsia

Author(s)

ZARE MARYAM | DOROUDCHI MEHRNOOSH | GHARESI FARD BEHROUZ | Issue Writer Certificate

Keywords

CD4

CD8

CD25

Foxp3

Pre-eclampsia

Pregnancy

Regulatory T cells

Abstract

Regulatory T cells are of utmost importance for tolerating the fetus. In some Pregnancy complications such as Pre-eclampsia, the frequency of CD4+CD25+Foxp3+ Regulatory T cells is altered, but there is no consistency regarding the results. Besides, little is known about the frequency of CD8+CD25+Foxp3+ Treg cells in Pregnancy complications. Therefore, we aimed to investigate the frequency of both CD4+ and CD8+ Regulatory T cells in the peripheral blood of women afflicted by preeclampsia. Ten non-pregnant, ten healthy pregnant, and ten preeclamptic women participated in this study. Four colors flow cytometry method was used to identify the frequency of the CD4+ and CD8+ Regulatory T cells in the peripheral blood. Results indicated that the frequencies of CD4+CD25+Foxp3+ and CD8+CD25+Foxp3+ cells were significantly lower in preeclamptic women compared to healthy pregnant and non-pregnant ones (p<0. 05). A positive correlation was also observed between CD4+ and CD8+ Regulatory T cells (R=0. 532, p=0. 002). Moreover, CD4+ Regulatory T cells negatively correlated with systolic and diastolic blood pressures (R=-0. 760 and-0. 753, respectively; p<0. 001). CD8+ Regulatory T cells also had a negative correlation with systolic (R=-0. 503, p=0. 001) and diastolic (R=-0. 590, p=0. 005) blood pressures. In conclusion, a reduction in the frequencies of both CD4+ CD25+ Foxp3+ and CD8+CD25+Foxp3+ Regulatory T cells might be important in the pathogenesis of Pre-eclampsia.

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APA: Copy

ZARE, MARYAM, DOROUDCHI, MEHRNOOSH, & GHARESI FARD, BEHROUZ. (2018). Altered Frequencies of CD4+ CD25+ Foxp3+ and CD8+ CD25+ Foxp3+ Regulatory T Cells in Pre-eclampsia. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 17(6), 540-547. SID. https://sid.ir/paper/291718/en

Vancouver: Copy

ZARE MARYAM, DOROUDCHI MEHRNOOSH, GHARESI FARD BEHROUZ. Altered Frequencies of CD4+ CD25+ Foxp3+ and CD8+ CD25+ Foxp3+ Regulatory T Cells in Pre-eclampsia. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2018;17(6):540-547. Available from: https://sid.ir/paper/291718/en

IEEE: Copy

MARYAM ZARE, MEHRNOOSH DOROUDCHI, and BEHROUZ GHARESI FARD, “Altered Frequencies of CD4+ CD25+ Foxp3+ and CD8+ CD25+ Foxp3+ Regulatory T Cells in Pre-eclampsia,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 17, no. 6, pp. 540–547, 2018, [Online]. Available: https://sid.ir/paper/291718/en

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