مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

406
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

249
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE CYTOTOXIC ACTIVITY OF VARIOUS HERBALS AGAINST DIFFERENT TUMOR CELLS: AN IN VITRO STUDY

Pages

  260-265

Abstract

 Background: Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal native plants on different tumor cell lines. Methods: Plants including SALVIA SANTOLINIFOLIA, SALVIA EREMOPHIL, SALVIA MACROSIPHON, SALVIA REUTERANA, TEUCRIUM PERSICUM, ANVILLEA GRACINI and FRANCOEURIA UNDULATe were collected from different sites of Fars Province in southern Iran. The methanolic extracts of the plants were prepared and their effects at concentrations of 5-200 mu g/ml on various tumor cell lines were examined using a colorimetric assay. Results: Among the extracts of Salvia species, the strongest inhibitory effect was observed for S. reuterana extract. This extract showed a strong cytotoxic effect on the Raji lymphoma cell line. More than 50% of Raji cells growth was inhibited by 21 mu g/ml of this extract. S. macrosiphon extract also showed a strong inhibitory effect on this tumor cell line (IC50=77+/-1 mu g/ml). The greatest inhibitory effect of T. persicum extract was on Hela tumor cell line. This extract at concentration of 69+/-2 mu g/ml causes 50% inhibition of Hela cell growth. Corresponding data for A. gracini extract was obtained at concentrations of 83.5+/-2 and 86+/-3 mu g/ml on Jurkat and Hela cells, respectively. F. undulata reduced the proliferation of all the tumor cell lines used in this study but this inhibition did not reach 50%. Conclusion: All the extracts, more and less, showed inhibitory effects on the tumor cell lines. The most cytotoxic activity was observed in S. reuterana with an IC50 value less than 25 mu g/ml towards Raji cell line. 

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    AMIR GHOFRAN, Z., ZAND, F., JAVIDNIA, K., & MIRI, R.. (2010). THE CYTOTOXIC ACTIVITY OF VARIOUS HERBALS AGAINST DIFFERENT TUMOR CELLS: AN IN VITRO STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 12(3), 260-265. SID. https://sid.ir/paper/292212/en

    Vancouver: Copy

    AMIR GHOFRAN Z., ZAND F., JAVIDNIA K., MIRI R.. THE CYTOTOXIC ACTIVITY OF VARIOUS HERBALS AGAINST DIFFERENT TUMOR CELLS: AN IN VITRO STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2010;12(3):260-265. Available from: https://sid.ir/paper/292212/en

    IEEE: Copy

    Z. AMIR GHOFRAN, F. ZAND, K. JAVIDNIA, and R. MIRI, “THE CYTOTOXIC ACTIVITY OF VARIOUS HERBALS AGAINST DIFFERENT TUMOR CELLS: AN IN VITRO STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 12, no. 3, pp. 260–265, 2010, [Online]. Available: https://sid.ir/paper/292212/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button