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Information Journal Paper

Title

ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND ACUTE TOXICITY EFFECTS OF JUGLANS REGIA L. LEAVES IN MICE

Pages

  27-33

Abstract

 Background: JUGLANS REGIA leaves have been used in folk medicine to alleviate inflammatory diseases. This study investigates the antinociceptive, anti-Inflammatory and acute toxicity effects ofJUGLANS REGIA L. leaves in MICE.Methods: 351 Male and female albino MICE were divided into negative (saline), positive (morphine or diclofenac) controls as well as test groups (n=6-8). The acute (intraperitoneally) toxicity was evaluated for 2 days. Antinociceptive activities were done using hot-plate and WRITHING TESTs. Anti-inflammatory effects were studied using xylene induced ear edema and COTTON PELLET TESTs.Results: The LD50 values of J. regia aqueous and ethanolic extrats were 5.5 and 3.3 g/kg, respectively. The aqueous (2.87 and 1.64 g/kg) and ethanolic (2.044 and 1.17 g/kg) extracts showed antinociceptive activity in hotplate test. The pretreatment of naloxone (2 mg/kg, s.c.) did not inhibit the extracts activities. The extracts exhibited antinociceptive activity in WRITHING TEST, which were not blocked by naloxone. In xylene test, both extracts showed anti-inflammatory activity in some doses. The extracts showed anti-inflammatory activity against the chronic inflammation.Conclusion: J. regia leaves demonstrated antinociceptive effect through non-opioid receptors and antiinflammatory effect against acute and chronic inflammation. The extracts ofJ. regia could be considered as a promising analgesic and anti-inflammatory agents against diseases such as rheumatoid arthritis.

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    APA: Copy

    HOSSEINZADEH, H., ZAREI, H., & TAGHIABADI, E.. (2011). ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND ACUTE TOXICITY EFFECTS OF JUGLANS REGIA L. LEAVES IN MICE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 13(1), 27-33. SID. https://sid.ir/paper/292309/en

    Vancouver: Copy

    HOSSEINZADEH H., ZAREI H., TAGHIABADI E.. ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND ACUTE TOXICITY EFFECTS OF JUGLANS REGIA L. LEAVES IN MICE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2011;13(1):27-33. Available from: https://sid.ir/paper/292309/en

    IEEE: Copy

    H. HOSSEINZADEH, H. ZAREI, and E. TAGHIABADI, “ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND ACUTE TOXICITY EFFECTS OF JUGLANS REGIA L. LEAVES IN MICE,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 13, no. 1, pp. 27–33, 2011, [Online]. Available: https://sid.ir/paper/292309/en

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