THE EFFECT OF CALENDULA OFFICINALIS IN THERAPY OF ACETIC ACID INDUCED ULCERATIVE COLITIS IN DOG AS AN ANIMAL MODEL

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MEHRABANI D.; ZIAEI M.; HOSSEINI S.V.; GHAHRAMANI L.; BANANZADEH A.M.; ASHRAF M.J.; AMINI A.; AMINI M.; TANIDEH NADER

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Journal Paper

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Journal: Iranian Red Crescent Medical Journal Year:2011 | Volume:13 | Issue:12 Page(s): 884-890

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Title

THE EFFECT OF CALENDULA OFFICINALIS IN THERAPY OF ACETIC ACID INDUCED ULCERATIVE COLITIS IN DOG AS AN ANIMAL MODEL

Author(s)

Keywords

ULCERATIVE COLITIS

ACETIC ACID

CALENDULA OFFICINALIS

THERAPY

DOG

Abstract

Background: In patients with ULCERATIVE COLITIS (UC), the repeated cycle of injury and repair of intestinal mucosa has been reported to increase the risk of colon cancer. So, a safe and efficient THERAPY is required for the treatment and prophylaxis for the disease. This study aims to investigate the efficacy of CALENDULA OFFICINALIS extract in treatment of experimentally induced ULCERATIVE COLITIS in DOG animal model.Methods: During fall 2010, 10 out-bred female German DOGs (1-2 years old; weighs of 20-25 kg) were enrolled. ULCERATIVE COLITIS was induced with 6% ACETIC ACID as enema and method of treatment was retrograde (via enema) too by C. officinalis.Results: Loose stools, diarrhea, gross bleeding and loss of body weight happened after administration of ACETIC ACID and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells were noticed histologically. C. officinalis could successfully resolve the damages of UC.Conclusion: Treatment with C. officinalis can broaden the current THERAPY options for UC.

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APA: Copy

MEHRABANI, D., ZIAEI, M., HOSSEINI, S.V., GHAHRAMANI, L., BANANZADEH, A.M., ASHRAF, M.J., AMINI, A., AMINI, M., & TANIDEH, NADER. (2011). THE EFFECT OF CALENDULA OFFICINALIS IN THERAPY OF ACETIC ACID INDUCED ULCERATIVE COLITIS IN DOG AS AN ANIMAL MODEL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 13(12), 884-890. SID. https://sid.ir/paper/292502/en

Vancouver: Copy

MEHRABANI D., ZIAEI M., HOSSEINI S.V., GHAHRAMANI L., BANANZADEH A.M., ASHRAF M.J., AMINI A., AMINI M., TANIDEH NADER. THE EFFECT OF CALENDULA OFFICINALIS IN THERAPY OF ACETIC ACID INDUCED ULCERATIVE COLITIS IN DOG AS AN ANIMAL MODEL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2011;13(12):884-890. Available from: https://sid.ir/paper/292502/en

IEEE: Copy

D. MEHRABANI, M. ZIAEI, S.V. HOSSEINI, L. GHAHRAMANI, A.M. BANANZADEH, M.J. ASHRAF, A. AMINI, M. AMINI, and NADER TANIDEH, “THE EFFECT OF CALENDULA OFFICINALIS IN THERAPY OF ACETIC ACID INDUCED ULCERATIVE COLITIS IN DOG AS AN ANIMAL MODEL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 13, no. 12, pp. 884–890, 2011, [Online]. Available: https://sid.ir/paper/292502/en

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