COMPARISON BETWEEN PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE WITH ITS ADMINISTRATION BEFORE AND DURING CONGENITAL HEART SURGERY ON SERUM LEVELS OF IL-6 AND IL-10

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TASHNIZI MOHAMMAD ABBASI; SOLTANI GHASEM; MOEINIPOUR ALI ASGHAR; AYATOLLAHI HOSSEIN; TANHA AMIR SABER; JARAHI LIDA; SEPEHRI SHAMLOO ALIREZA; ZIRAK NAHID

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Journal: Iranian Red Crescent Medical Journal Year:2013 | Volume:15 | Issue:2 Page(s): 147-151

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Title

COMPARISON BETWEEN PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE WITH ITS ADMINISTRATION BEFORE AND DURING CONGENITAL HEART SURGERY ON SERUM LEVELS OF IL-6 AND IL-10

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Keywords

CARDIOPULMONARY BYPASS

HEART DEFECTS

CONGENITAL

INTERLEUKINS

INFLAMMATION

Abstract

Background: Steroid administration during CARDIOPULMONARY BYPASS is considered to improve cardiopulmonary function by modulating INFLAMMATIONs caused by bypass.Objectives: This study was performed to compare effectiveness of preoperative and intraoperative methylprednisolone (MP) to preoperative methylprednisolone alone in post bypass inflammatory (IL-6) and anti-inflammatory (IL-10) factors.Patients and Methods: Fifty pediatric patients undergoing CARDIOPULMONARY BYPASS surgery from August 2011 to 2012 in the cardiac surgery department of Imam Reza Hospital, the major center for CPB, in Mashhad, Iran were randomly assigned to receive preoperative and intraoperative MP (30 mg/kg, 4 hours before bypass and in bypass prime, number 25) or preoperative MP only (30 mg/kg, number 25). Before and after bypass, four and 24 hours after bypass, serum IL-6 and IL-10 were measured by ELISA.Results: In both groups, no significant difference with variation of expression for IL-6 (inflammatory factor) and IL-10 (anti-inflammatory factor) in different times after bypass was observed.Conclusions: No significant difference in reducing post bypass INFLAMMATION between preoperative steroid treatment and combined preoperative and intraoperative steroid administration reported and they had the same effects.

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APA: Copy

TASHNIZI, MOHAMMAD ABBASI, SOLTANI, GHASEM, MOEINIPOUR, ALI ASGHAR, AYATOLLAHI, HOSSEIN, TANHA, AMIR SABER, JARAHI, LIDA, SEPEHRI SHAMLOO, ALIREZA, & ZIRAK, NAHID. (2013). COMPARISON BETWEEN PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE WITH ITS ADMINISTRATION BEFORE AND DURING CONGENITAL HEART SURGERY ON SERUM LEVELS OF IL-6 AND IL-10. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(2), 147-151. SID. https://sid.ir/paper/292818/en

Vancouver: Copy

TASHNIZI MOHAMMAD ABBASI, SOLTANI GHASEM, MOEINIPOUR ALI ASGHAR, AYATOLLAHI HOSSEIN, TANHA AMIR SABER, JARAHI LIDA, SEPEHRI SHAMLOO ALIREZA, ZIRAK NAHID. COMPARISON BETWEEN PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE WITH ITS ADMINISTRATION BEFORE AND DURING CONGENITAL HEART SURGERY ON SERUM LEVELS OF IL-6 AND IL-10. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(2):147-151. Available from: https://sid.ir/paper/292818/en

IEEE: Copy

MOHAMMAD ABBASI TASHNIZI, GHASEM SOLTANI, ALI ASGHAR MOEINIPOUR, HOSSEIN AYATOLLAHI, AMIR SABER TANHA, LIDA JARAHI, ALIREZA SEPEHRI SHAMLOO, and NAHID ZIRAK, “COMPARISON BETWEEN PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE WITH ITS ADMINISTRATION BEFORE AND DURING CONGENITAL HEART SURGERY ON SERUM LEVELS OF IL-6 AND IL-10,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 2, pp. 147–151, 2013, [Online]. Available: https://sid.ir/paper/292818/en

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