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Title

SERUM FERRITIN LEVELS CORRELATION WITH HEART AND LIVER MRI AND LIC IN PATIENTS WITH TRANSFUSION-DEPENDENT THALASSEMIA

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Abstract

 Background: Iron-loaded cardiac complication is the essential cause of mortality in patients with thalassemia. Early detection and treatment of cardiac over-load can reduce mortality.Objectives: The current study aimed to evaluate the relationship between serum FERRITIN levels and T2* MAGNETIC RESONANCE IMAGING (MRI) of HEART and LIVER and LIVER iron concentration (LIC) to diagnose iron over load in countries with limited access.Patients and Methods: In the current cross-sectional study, 85 Iranian patients with thalassemia with the mean age of 22.7±7 years were randomly selected. All patients were on regular blood transfusion. Echocardiography of HEART and LIVER T2* MRI, determination of serum FERRITIN levels, and LIC were performed in all subjects at the same time. The correlation of serum FERRITIN levels with T2*MRI of HEART and LIVER, and LIC was assessed. P value<0.05 was considered statistically significant.Results: Abnormal myocardial iron load (T2* MRI<20 ms) was detected in 58% of the patients and among whom, 36% had severe myocardial iron load (T2* MRI<10 ms). Median and interquartile range of serum FERRITIN levels were 1434 and 2702 respectively in patients with thalassemia. Serum FERRITIN levels showed a statistically significant positive correlation with LIC (rs=0.718, P<0.001) and significant negative correlation with T2* HEART (rs=-0.329, P=0.002), and T2* LIVER (rs=-0.698, P<0.001). However, Ejection fraction was not significantly correlated with serum FERRITIN levels in the patients (P=0.399).Conclusions: Serum FERRITIN levels can be used to diagnose iron over-load in patients with thalassemiaas an alternative method in areas where T2* MRI is not available.

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    APA: Copy

    MAJD, ZAHRA, HAGHPANAH, SEZANEH, AJAMI, GHOLAMHOSSEIN, MATIN, SARA, NAMAZI, HAMID, BARDESTANI, MARZIEH, & KARIMI, MEHRAN. (2015). SERUM FERRITIN LEVELS CORRELATION WITH HEART AND LIVER MRI AND LIC IN PATIENTS WITH TRANSFUSION-DEPENDENT THALASSEMIA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(4), 0-0. SID. https://sid.ir/paper/292949/en

    Vancouver: Copy

    MAJD ZAHRA, HAGHPANAH SEZANEH, AJAMI GHOLAMHOSSEIN, MATIN SARA, NAMAZI HAMID, BARDESTANI MARZIEH, KARIMI MEHRAN. SERUM FERRITIN LEVELS CORRELATION WITH HEART AND LIVER MRI AND LIC IN PATIENTS WITH TRANSFUSION-DEPENDENT THALASSEMIA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(4):0-0. Available from: https://sid.ir/paper/292949/en

    IEEE: Copy

    ZAHRA MAJD, SEZANEH HAGHPANAH, GHOLAMHOSSEIN AJAMI, SARA MATIN, HAMID NAMAZI, MARZIEH BARDESTANI, and MEHRAN KARIMI, “SERUM FERRITIN LEVELS CORRELATION WITH HEART AND LIVER MRI AND LIC IN PATIENTS WITH TRANSFUSION-DEPENDENT THALASSEMIA,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 4, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/292949/en

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