EFFECT OF IMMEDIATE DECOMPRESSION IN COMPLETE SPINAL CORD INJURY IN RATS

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YAZDI A.; RAHIMI MOVAGHAR V.; KARIMI MEHRBOD; MOHAMMADI M.

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Journal: HAKIM RESEARCH JOURNAL Year:2006 | Volume:8 | Issue:4 Page(s): 52-59

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Information Journal Paper

Title

EFFECT OF IMMEDIATE DECOMPRESSION IN COMPLETE SPINAL CORD INJURY IN RATS

Author(s)

YAZDI A. | RAHIMI MOVAGHAR V. | KARIMI MEHRBOD | MOHAMMADI M. | Issue Writer Certificate

Keywords

SPINAL CORD INJURYQ4

SURGERYQ3

DECOMPRESSIONQ3

RATSQ3

Abstract

Introduction: The value of DECOMPRESSION SURGERY after complete SPINAL CORD INJURY is controversial. This study examines whether DECOMPRESSION is useful in paraplegic (not paraparetic) RATS and, if so, what the optimim time is after injury. Methods: The spinal cords of 126 female RATS were compressed at thoracic level 9 with a mini Yasargil clips. RATS were assigned to 5 case groups, and one sham-operated group. Clips were removed after 3 seconds (3s), 1 hour (1h), 6h, 3 weeks (3w), or no DECOMPRESSION. Locomotor behavior scoring categories ranked based on the BBB Locomotor Rating Scale. Under histopathologic evaluation, the maximum surface (%) of damaged area was measured and the severity of inflammation, congestion and hemorrhage, necrosis, fibrosis and gliosis were evaluated in double-blind manner. Results: There was not significant difference in survival among all groups of compressed spinal cord. There was neither statistically meaningful difference nor progressive changes in BBB except for 3s group at 4, 11, 18, 25, 32, 39, 46-days (p<0.05). In complete spinal cord injured RATS, a good correlation between absence of tail reflex and consistency of zero BBB was found. Mean ranking percent of damaged surface area revealed significant difference between damaged groups (P=0.039). Conclusions: Very early spinal cord DECOMPRESSION is useful in traumatic paraplegia in RATS. Absence of tail reflex shows poor prognosis.

Cites

SATURATED PICRIC ACID PREVENTS AUTOPHAGIA AND SELF-MUTILATION IN LABORATORY RATS

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APA: Copy

YAZDI, A., RAHIMI MOVAGHAR, V., KARIMI, MEHRBOD, & MOHAMMADI, M.. (2006). EFFECT OF IMMEDIATE DECOMPRESSION IN COMPLETE SPINAL CORD INJURY IN RATS. HAKIM RESEARCH JOURNAL, 8(4), 52-59. SID. https://sid.ir/paper/29295/en

Vancouver: Copy

YAZDI A., RAHIMI MOVAGHAR V., KARIMI MEHRBOD, MOHAMMADI M.. EFFECT OF IMMEDIATE DECOMPRESSION IN COMPLETE SPINAL CORD INJURY IN RATS. HAKIM RESEARCH JOURNAL[Internet]. 2006;8(4):52-59. Available from: https://sid.ir/paper/29295/en

IEEE: Copy

A. YAZDI, V. RAHIMI MOVAGHAR, MEHRBOD KARIMI, and M. MOHAMMADI, “EFFECT OF IMMEDIATE DECOMPRESSION IN COMPLETE SPINAL CORD INJURY IN RATS,” HAKIM RESEARCH JOURNAL, vol. 8, no. 4, pp. 52–59, 2006, [Online]. Available: https://sid.ir/paper/29295/en

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