SATURATED PICRIC ACID PREVENTS AUTOPHAGIA AND SELF-MUTILATION IN LABORATORY RATS

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RAHIMI MOVAGHAR V.; YAZDI A.; SAADAT S.

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Journal Paper

Paper Information

Journal: ACTA MEDICA IRANICA Year:2008 | Volume:46 | Issue:4 Page(s): 283-286

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Information Journal Paper

Title

SATURATED PICRIC ACID PREVENTS AUTOPHAGIA AND SELF-MUTILATION IN LABORATORY RATS

Author(s)

RAHIMI MOVAGHAR V. | YAZDI A. | SAADAT S. | Issue Writer Certificate

Keywords

AUTOPHAGIA

SELF-MUTILATION BEHAVIOR

RAT

SPINAL CORD INJURY

Abstract

The dysesthesia and paresthesia that occurs in laboratory RATs after SPINAL CORD INJURY (SCI) results in AUTOPHAGIA. This self-destructive behavior interferes with functional assessments in designed studies and jeopardizes the health of the injured RAT. In this study, we evaluated role of saturated picric acid in the prevention of AUTOPHAGIA and self-mutilation. All RATs were anesthetized with an intraperitoneal injection of a mixture of ketamine (100 mg/kg) and xylazine (10 mg/kg) for the SCI procedures. In the first 39 RATs, no solution applied to the hind limbs, but in the next 26 cases, we smeared the saturated picric acid on the tail, lower extremities, pelvic, and abdomen of the RATs immediately after SCI. In the RATs without picric acid, 23 RATs died following AUTOPHAGIA, but in the 26 RATs with picric acid, there was no AUTOPHAGIA (P < 0.001). Picric acid side effects in skin and gastrointestinal signs such as irritation, redness and diarrhea were not seen in any RAT. Saturated picric acid is a topical solution that if used appropriately and carefully, might be safe and effectively prevents AUTOPHAGIA and self-mutilation. When the solution is applied to the lower abdomen and limbs, we presume that its bitterness effectively prevents the RAT from licking and biting the limb.

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APA: Copy

RAHIMI MOVAGHAR, V., YAZDI, A., & SAADAT, S.. (2008). SATURATED PICRIC ACID PREVENTS AUTOPHAGIA AND SELF-MUTILATION IN LABORATORY RATS. ACTA MEDICA IRANICA, 46(4), 283-286. SID. https://sid.ir/paper/278134/en

Vancouver: Copy

RAHIMI MOVAGHAR V., YAZDI A., SAADAT S.. SATURATED PICRIC ACID PREVENTS AUTOPHAGIA AND SELF-MUTILATION IN LABORATORY RATS. ACTA MEDICA IRANICA[Internet]. 2008;46(4):283-286. Available from: https://sid.ir/paper/278134/en

IEEE: Copy

V. RAHIMI MOVAGHAR, A. YAZDI, and S. SAADAT, “SATURATED PICRIC ACID PREVENTS AUTOPHAGIA AND SELF-MUTILATION IN LABORATORY RATS,” ACTA MEDICA IRANICA, vol. 46, no. 4, pp. 283–286, 2008, [Online]. Available: https://sid.ir/paper/278134/en

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