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Title

DECREASED ACTIVITY IN NEUROPATHIC PAIN FORM AND GENE EXPRESSION OF CYCLIN-DEPENDENT KINASE5 AND GLYCOGEN SYNTHASE KINASE-3 BETA IN SOLEUS MUSCLE OF WISTAR MALE RATS

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Abstract

 Background: The relationship between decreased activity/NEUROPATHIC PAIN and gene expression alterations in SOLEUS MUSCLE has remained elusive.Objectives: In this experimental study, we investigated the effects of decreased activity in NEUROPATHIC PAIN form on Cyclin-Dependent Kinase 5 (CDK5) and Glycogen Synthase Kinase-3 b (GSK-3b) gene expression in SOLEUS MUSCLE of rats.Materials and Methods: Twelve male Wistar rats were randomly divided into three groups: (1) tight ligation of the L5 spinal nerve (SNL: n=4); (2) sham surgery (Sham: n=4), and (3) control (C: n=4). The threshold to produce a withdrawal response to a mechanical and thermal stimulus was measured using von Frey filaments and radiation heat apparatus, respectively. Following 4 weeks after surgery, the left SOLEUS MUSCLE was removed and mRNA levels were determined by real-time Polymerase Chain Reaction (PCR).Results: Compared to control animals, L5 ligated animals developed mechanical and heat hypersensitivity during total period of study. SOLEUS MUSCLE weight as well as CDK5 mRNA levels (less than~0.4 fold) was decreased and GSK-3b mRNA levels (up to~7 folds) increased in L5 ligated animals.Conclusions: These results showed enhanced muscle atrophy processes following peripheral nerve damage and might provide a useful approach to study underlying muscle mechanisms associated with clinical NEUROPATHIC PAIN syndromes.

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    APA: Copy

    RAHMATI, MASOUD, TAHERABAD, SEYED JALAL, & MEHRABI, MAHMOUD. (2015). DECREASED ACTIVITY IN NEUROPATHIC PAIN FORM AND GENE EXPRESSION OF CYCLIN-DEPENDENT KINASE5 AND GLYCOGEN SYNTHASE KINASE-3 BETA IN SOLEUS MUSCLE OF WISTAR MALE RATS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(6), 0-0. SID. https://sid.ir/paper/292973/en

    Vancouver: Copy

    RAHMATI MASOUD, TAHERABAD SEYED JALAL, MEHRABI MAHMOUD. DECREASED ACTIVITY IN NEUROPATHIC PAIN FORM AND GENE EXPRESSION OF CYCLIN-DEPENDENT KINASE5 AND GLYCOGEN SYNTHASE KINASE-3 BETA IN SOLEUS MUSCLE OF WISTAR MALE RATS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(6):0-0. Available from: https://sid.ir/paper/292973/en

    IEEE: Copy

    MASOUD RAHMATI, SEYED JALAL TAHERABAD, and MAHMOUD MEHRABI, “DECREASED ACTIVITY IN NEUROPATHIC PAIN FORM AND GENE EXPRESSION OF CYCLIN-DEPENDENT KINASE5 AND GLYCOGEN SYNTHASE KINASE-3 BETA IN SOLEUS MUSCLE OF WISTAR MALE RATS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/292973/en

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