OVEREXPRESSION OF HER2/NEU AS A PROGNOSTIC VALUE IN IRANIAN WOMEN WITH EARLY STAGE BREAST CANCER, A SINGLE INSTITUTE STUDY

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MIRTAVOOS MAHYARI HANIFEH; KHOSRAVI ADNAN; MIRTAVOOS MAHYARI ZEINAB; ESFAHANI MONFARED ZAHRA; KHOSRAVI NEGIN

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Journal: Iranian Red Crescent Medical Journal Year:2014 | Volume:16 | Issue:11 Page(s): 0-0

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Title

OVEREXPRESSION OF HER2/NEU AS A PROGNOSTIC VALUE IN IRANIAN WOMEN WITH EARLY STAGE BREAST CANCER, A SINGLE INSTITUTE STUDY

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Keywords

BREAST NEOPLASMS

ONCOGENES

BIOLOGICAL MARKERS

Abstract

Background: Patients with early stage breast cancer with same treatment strategy can have markedly different outcomes. Human epidermal growth factor receptor 2 (HER2/nue) gene amplification or the subsequent overexpression of protein has been proved to be associated with patient's outcome and response to anthracyclins-based regimens.Objectives: This study assessed prognostic value of HER2/nue marker in patients with early stage breast cancer who received adjuvant chemotherapy with anthracyclins-based regimens.Materials and Methods: Fifty tissue samples from patients with primary breast cancer of moderate risk receiving sequential adjuvant chemotherapy with anthracyclins-based regimens were assessed to evaluate HER2/nue gene status (quantified by Immunohistochemistry and fluorescence in situ hybridization) retrospectively. Besides, correlation of HER2/neu with patients' characteristics and outcome was studied.Results: HER2/neu amplification was identified in 19 (38%) of 50 patients. No significant difference regarding HER2/neu status was seen in clinic pathological characteristics of patients. Although Progression Free Survival (PFS) was shorter in HER2 overexpressed group, but uni/multivariate analysis adjusted for HER2 overexpression, nodal involvement, hormone receptor status, age and tumor size revealed no significant predictive and/or prognostic value for HER2 regarding PFS.Conclusions: This study on a limited number of patients treated with adjutant anthracyclins-based regimens, revealed that HER2/neu is not a unique strong predictor for outcome, thus according to combination of HER2/neu status and other clinical factors, it is necessary to distinguish patients at high risk of recurrence.

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APA: Copy

MIRTAVOOS MAHYARI, HANIFEH, KHOSRAVI, ADNAN, MIRTAVOOS MAHYARI, ZEINAB, ESFAHANI MONFARED, ZAHRA, & KHOSRAVI, NEGIN. (2014). OVEREXPRESSION OF HER2/NEU AS A PROGNOSTIC VALUE IN IRANIAN WOMEN WITH EARLY STAGE BREAST CANCER, A SINGLE INSTITUTE STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 16(11), 0-0. SID. https://sid.ir/paper/293003/en

Vancouver: Copy

MIRTAVOOS MAHYARI HANIFEH, KHOSRAVI ADNAN, MIRTAVOOS MAHYARI ZEINAB, ESFAHANI MONFARED ZAHRA, KHOSRAVI NEGIN. OVEREXPRESSION OF HER2/NEU AS A PROGNOSTIC VALUE IN IRANIAN WOMEN WITH EARLY STAGE BREAST CANCER, A SINGLE INSTITUTE STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2014;16(11):0-0. Available from: https://sid.ir/paper/293003/en

IEEE: Copy

HANIFEH MIRTAVOOS MAHYARI, ADNAN KHOSRAVI, ZEINAB MIRTAVOOS MAHYARI, ZAHRA ESFAHANI MONFARED, and NEGIN KHOSRAVI, “OVEREXPRESSION OF HER2/NEU AS A PROGNOSTIC VALUE IN IRANIAN WOMEN WITH EARLY STAGE BREAST CANCER, A SINGLE INSTITUTE STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 16, no. 11, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/293003/en

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