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Information Journal Paper

Title

GASTROINTESTINAL COMPLICATIONS OF FERROUS SULFATE IN PREGNANT WOMEN: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

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Abstract

 Background: Some PREGNANT WOMEN discontinue IRON SUPPLEMENTs consumption due to Gastrointestinal (GI) complications, whereas pregnancy induces the same complications physiologically.Objectives: The aim of the present study was to assess GI complications of ferrous sulfate in PREGNANT WOMEN.Patients and Methods: This randomized, double-blind, placebo-controlled clinical trial was performed on 176 PREGNANT WOMEN referred to prenatal care clinic of Maryam Hospital from April 2011 to February 2012. PREGNANT WOMEN with Hb ³ 13.2 gr/dL at 13th -18th weeks of gestation were selected based on the inclusion criteria and were randomly assigned to the ferrous sulfate and placebo groups. The ferrous sulfate group (n=90) received a 50-mg ferrous sulfate tablet daily from the 20th week to the end of pregnancy and the placebo group (n=89) received one placebo tablet in the same way. All participants were visited twice at 24th - 28th and 32nd - 36th weeks to assess the GI complications as well as Hb level to determine the Hb changes in two groups. Chi-square test, t-test and Kolmogorov-Smirnov test were used to analyze the data. P value of<0.05 and confidence level of 95% were considered as statistically significant.Results: None of the GI complications were significantly different between the ferrous sulfate and placebo groups at 24th - 28th and 32nd - 36th weeks. HEMOGLOBIN drop lower than 10.5 gr/dL at 24th - 28th weeks or lower than 11 g/dL at 32nd - 36th weeks was not observed in any cases.Conclusions: It can be concluded that GI complications in PREGNANT WOMEN using ferrous sulfate are mostly caused by physiologic changes of pregnancy rather than ferrous sulfate; therefore, it is not reasonable to stop using ferrous sulfate due to GI complications.

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    APA: Copy

    JAFARBEGLOO, ESMAT, AHMARI TEHRAN, HODA, & DADKHAH TEHRANI, TAHMINEH. (2015). GASTROINTESTINAL COMPLICATIONS OF FERROUS SULFATE IN PREGNANT WOMEN: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(8), 0-0. SID. https://sid.ir/paper/293107/en

    Vancouver: Copy

    JAFARBEGLOO ESMAT, AHMARI TEHRAN HODA, DADKHAH TEHRANI TAHMINEH. GASTROINTESTINAL COMPLICATIONS OF FERROUS SULFATE IN PREGNANT WOMEN: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(8):0-0. Available from: https://sid.ir/paper/293107/en

    IEEE: Copy

    ESMAT JAFARBEGLOO, HODA AHMARI TEHRAN, and TAHMINEH DADKHAH TEHRANI, “GASTROINTESTINAL COMPLICATIONS OF FERROUS SULFATE IN PREGNANT WOMEN: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 8, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/293107/en

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