مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

BRIEF REPORT: SMALL CELL CARCINOMA OF THE ESOPHAGUS: CLINICOPATHOLOGICAL FEATURES AND OUTCOME OF 22 CASES

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Abstract

 Background: Small cell esophageal carcinoma (SCEC) is a highly aggressive and rare neoplasm.Objectives: This study aimed to report the characteristics, prognostic factors, and treatment outcomes of 22 patients with SCEC.Patients and Methods: This brief report was carried out by reviewing the medical records of 22 patients with newly histologically proven SCEC that were treated between 2000 and 2010 at 2 tertiary academic hospitals. All the potential prognostic variables, including the patients’ characteristics, tumor features, and treatment modalities were analyzed to establish their influence on the patients’ survival rates.Results: This study was conducted on 7 males and 15 females with a median age of 61 years. Dysphagia and weight loss were the most prevalent symptoms. According to the results, 14 patients (64%) had limited diseases and 8 cases (36%) had extensive diseases. In those with extensive diseases, liver, lung, and lymph nodes (LNs) were the most metastatic sites. Besides, most tumors were located in lower (50%) and middle (32%) part of the ESOPHAGUS. Most patients (91%) were treated with sequential (55%) or concurrent (36%) chemoradiation (CRT). Surgical resection was also performed for 7 patients. CHEMOTHERAPY regimen consisted of cisplatin and etoposide in 14 patients (64%). The median follow up time was 12 months. The 1, 3, and 5-year overall survival rates were 27%, 14%, and 4%, respectively. Yet, no prognostic factors were found because of the small sample size of the study.Conclusions: Primary SCEC is a rare and highly aggressive tumor. However, PROGNOSIS is poor and long-term survival is exceptional. CRT could be an appropriate alternative to operation.

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    APA: Copy

    HOSSEINI, SARE, SALEK, ROHAM, NASROLAHI, HAMID, MOHAMMADIANPANAH, MOHAMMAD, & JUDI, MONA. (2015). BRIEF REPORT: SMALL CELL CARCINOMA OF THE ESOPHAGUS: CLINICOPATHOLOGICAL FEATURES AND OUTCOME OF 22 CASES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(11), 0-0. SID. https://sid.ir/paper/293122/en

    Vancouver: Copy

    HOSSEINI SARE, SALEK ROHAM, NASROLAHI HAMID, MOHAMMADIANPANAH MOHAMMAD, JUDI MONA. BRIEF REPORT: SMALL CELL CARCINOMA OF THE ESOPHAGUS: CLINICOPATHOLOGICAL FEATURES AND OUTCOME OF 22 CASES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(11):0-0. Available from: https://sid.ir/paper/293122/en

    IEEE: Copy

    SARE HOSSEINI, ROHAM SALEK, HAMID NASROLAHI, MOHAMMAD MOHAMMADIANPANAH, and MONA JUDI, “BRIEF REPORT: SMALL CELL CARCINOMA OF THE ESOPHAGUS: CLINICOPATHOLOGICAL FEATURES AND OUTCOME OF 22 CASES,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 11, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/293122/en

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