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Information Journal Paper

Title

EFFICACY OF TRIGONELLA FOENUM-GRAECUM SEED EXTRACT IN REDUCING METABOLIC AND INFLAMMATORY ALTERATIONS ASSOCIATED WITH MENOPAUSE

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Abstract

 Background: Several experimental and clinical studies support beneficial effects of TRIGONELLA FOENUM-GRAECUM (fenugreek) in the management of metabolic diseases and inflammatory disorders.Objectives: The purpose of this study was to examine the effect of T. foenum-graecum seed extract in reducing the metabolic and inflammatory alternations associated with MENOPAUSE.Materials and Methods: In this experimental study, 49 RATS were divided into seven groups: (I) sham-control, (II) ovariectomized-control, (III and IV) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum seed ethanolic extract, (V and VI) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum hexanic extract, (VII) ovariectomized-positive control treated with 10 μg/kg of estradiol. The extracts were injected intraperitoneally one day after ovariectomy and the treatments were lasted for 42 days.Results: Fasting blood glucose and body weight gain increased significantly in the ovariectomized-control group compared with that in the sham animals (P<0.05). Administration of estradiol and T. foenum-graecum (50 and 150 mg/dL of hexanic extract and 150 mg/kg of ethanolic extract) significantly diminished the increase in glucose and body weight (P<0.05). The serum level of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a) in the ovariectomized control group was significantly higher than those in the sham animals (P<0.05). Both hexanic and ethanolic extracts as well as estradiol were able to decrease level of these CYTOKINES in the serum of ovariectomized RATS (P<0.05).Conclusions: The results of the present study show that administration of T. foenum-graecum corrects metabolic and inflammatory alterations associated with ovariectomy and has a potential for the management of MENOPAUSE.

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    APA: Copy

    ABEDINZADE, MAHMOOD, NASRI, SIMA, JAMAL OMODI, MASOME, GHASEMI, ELHAM, & GHORBANI, AHMAD. (2015). EFFICACY OF TRIGONELLA FOENUM-GRAECUM SEED EXTRACT IN REDUCING METABOLIC AND INFLAMMATORY ALTERATIONS ASSOCIATED WITH MENOPAUSE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(11), 0-0. SID. https://sid.ir/paper/293130/en

    Vancouver: Copy

    ABEDINZADE MAHMOOD, NASRI SIMA, JAMAL OMODI MASOME, GHASEMI ELHAM, GHORBANI AHMAD. EFFICACY OF TRIGONELLA FOENUM-GRAECUM SEED EXTRACT IN REDUCING METABOLIC AND INFLAMMATORY ALTERATIONS ASSOCIATED WITH MENOPAUSE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(11):0-0. Available from: https://sid.ir/paper/293130/en

    IEEE: Copy

    MAHMOOD ABEDINZADE, SIMA NASRI, MASOME JAMAL OMODI, ELHAM GHASEMI, and AHMAD GHORBANI, “EFFICACY OF TRIGONELLA FOENUM-GRAECUM SEED EXTRACT IN REDUCING METABOLIC AND INFLAMMATORY ALTERATIONS ASSOCIATED WITH MENOPAUSE,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 11, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/293130/en

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