مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

IMMUNOHISTOCHEMICAL ASSESSMENT OF HER3 EXPRESSION IN ODONTOGENIC CYSTS

Pages

  0-0

Abstract

 Background: It has been demonstrated that HER3 plays an important role in some human cancers and the HER3 expression is associated with worse survival in solid tumors.Objectives: This study was conducted to compare HER3 expression in epithelial lining of RADICULAR CYSTs (RCs), DENTIGEROUS CYSTs (DCs) and odontogenic keratocysts (OKCs).Materials and Methods: This was a descriptive-analytical study, which assessed all 57 paraffin blocks of RCs, DCs and OKCs (21 RCs, 16 DCs, 20 OKC) from pathological archive of Dentistry College of Zahedan, Iran. The HER3 expression in cytoplasm and membrane was examined by immunohistochemical method. The data collected was analyzed using SPSS16 by ANOVA and Chi-square. P<0.05 was considered as statistically significant.Results: The HER3 expression had positive results in 52.4% of OKC, 50% of DC and only 20% of RC samples. There was a significant difference between HER3 expression in OKCs and RCs.Conclusions: The HER3 expression in developmental ODONTOGENIC CYSTS was higher than that in inflammatory ODONTOGENIC CYSTS. The higher rate of HER3 expression in OKC may justify inherent growth potential, stimulation-independent proliferation capability, invasive growth and high recurrence rate of the cyst accepted today as a tumor.

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    APA: Copy

    HONARMAND, MARIEH, SARAVANI, SHIRIN, KAMYAB, NAZANIN, JAHANTIGH, MEHDI, & TORABI PARIZI, MOLOUK. (2015). IMMUNOHISTOCHEMICAL ASSESSMENT OF HER3 EXPRESSION IN ODONTOGENIC CYSTS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(11), 0-0. SID. https://sid.ir/paper/293132/en

    Vancouver: Copy

    HONARMAND MARIEH, SARAVANI SHIRIN, KAMYAB NAZANIN, JAHANTIGH MEHDI, TORABI PARIZI MOLOUK. IMMUNOHISTOCHEMICAL ASSESSMENT OF HER3 EXPRESSION IN ODONTOGENIC CYSTS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(11):0-0. Available from: https://sid.ir/paper/293132/en

    IEEE: Copy

    MARIEH HONARMAND, SHIRIN SARAVANI, NAZANIN KAMYAB, MEHDI JAHANTIGH, and MOLOUK TORABI PARIZI, “IMMUNOHISTOCHEMICAL ASSESSMENT OF HER3 EXPRESSION IN ODONTOGENIC CYSTS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 11, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/293132/en

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