THE EFFECTS OF ORAL CRYOTHERAPY ON CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANTATION OF BLOOD STEM CELLS: A CLINICAL TRIAL

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ASKARIFAR MARZIEH; LAKDIZAJI SIMA; RAMZI MANI; RAHMANI AZAD; JABBARZADEH FARANAK

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:4 Page(s): 0-0

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Title

THE EFFECTS OF ORAL CRYOTHERAPY ON CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANTATION OF BLOOD STEM CELLS: A CLINICAL TRIAL

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Keywords

CHEMOTHERAPY

MUCOSITIS

STEM CELL TRANSPLANTATION

AUTOLOGOUS

CRYOTHERAPY

NORMAL SALINE

Abstract

Background: Oral MUCOSITIS is one of the irritating side effects of CHEMOTHERAPY in patients undergoing bone marrow transplantation. However, up until now, the common methods of oral MUCOSITIS therapy have failed to show significant effects.Objectives: The aim of this study was to investigate the effects of local CRYOTHERAPY on the intensity of CHEMOTHERAPY-induced oral MUCOSITIS in AUTOLOGOUS bone marrow transplantation patients.Patients and Methods: In this single, blinded, randomized clinical trial, 29 patients undergoing STEM CELL TRANSPLANTATION in Iran were selected by convenience sampling, and randomly allocated to control (n=13) and intervention groups (n=16). In the intervention group, CRYOTHERAPY was applied, while the control group received a NORMAL SALINE mouthwash. The severity of the MUCOSITIS and neutrophil rate were investigated in five periods, based on the world health organization (WHO) scales. The data were analyzed using descriptive statistics, the Mann-Whitney test, repeated measures analysis of variance (ANOVA), and linear regression.Results: In both groups, the MUCOSITIS reached its peak intensity on the 7th day, and the least intensity was obtained on the 21st day. The neutrophil rate reached the minimum value on the 7th day, then increased up to the 21st day. The two groups showed no significant differences between the MUCOSITIS severity on the 14th and 21st days (P=0.164), while the severity of the MUCOSITIS in the CRYOTHERAPY group was significantly less than that in the saline mouthwash group (1.81<2.54 and 0.13<0.92, respectively) on the 7th and 14th days (P<0.05). There was no significant difference in the neutrophil rate between the groups.Conclusions: The results showed that CRYOTHERAPY is more effective than the saline mouthwash in reducing the severity of MUCOSITIS. This method is recommended for the prevention of MUCOSITIS in bone marrow transplantation.

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APA: Copy

ASKARIFAR, MARZIEH, LAKDIZAJI, SIMA, RAMZI, MANI, RAHMANI, AZAD, & JABBARZADEH, FARANAK. (2016). THE EFFECTS OF ORAL CRYOTHERAPY ON CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANTATION OF BLOOD STEM CELLS: A CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(4), 0-0. SID. https://sid.ir/paper/293215/en

Vancouver: Copy

ASKARIFAR MARZIEH, LAKDIZAJI SIMA, RAMZI MANI, RAHMANI AZAD, JABBARZADEH FARANAK. THE EFFECTS OF ORAL CRYOTHERAPY ON CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANTATION OF BLOOD STEM CELLS: A CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(4):0-0. Available from: https://sid.ir/paper/293215/en

IEEE: Copy

MARZIEH ASKARIFAR, SIMA LAKDIZAJI, MANI RAMZI, AZAD RAHMANI, and FARANAK JABBARZADEH, “THE EFFECTS OF ORAL CRYOTHERAPY ON CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANTATION OF BLOOD STEM CELLS: A CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293215/en

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