ENIGMATIC INV(9): A CASE REPORT ON RARE FINDINGS IN HEMATOLOGICAL MALIGNANCIES

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VIJAY SANGEETHA; NARAYANAN GEETHA; SAROJAM SANTHI; RAVEENDRAN SURESHKUMAR; SREEDHARAN HARIHARAN

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:4 Page(s): 0-0

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Title

ENIGMATIC INV(9): A CASE REPORT ON RARE FINDINGS IN HEMATOLOGICAL MALIGNANCIES

Author(s)

Keywords

CHROMOSOME 9

INVERSION

CHRONIC MYELOGENOUS LEUKEMIA

BCR-ABL POSITIVE

CHRONIC MYELOPROLIFERATIVE DISORDER

Abstract

Introduction: INVERSION of CHROMOSOME 9 had been widely discussed among geneticists and evolutionary biologists because of its significant impact on various hereditary disorders and in the evolution of man. The role of such INVERSIONs in human disease evolution is an area hitherto unclear.Case Presentation: We present the case of a chronic myeloid leukemia (CML) patient who showed intermittent relapse on treatment, with a rare appearance of clones with dual INVERSION (9) breakpoints [inv (9) (p22q34); inv (9) (p11q21)]. We also present the first report of inv (9) (p11, q13) as the sole abnormality in a patient with CHRONIC MYELOPROLIFERATIVE DISORDER (CMPD). Both the patients registered in 2012 and were from Kerala, India.Conclusions: Both the cases discussed in our study have inv (9) as the sole abnormality and are found to confer a relatively poor prognosis.

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APA: Copy

VIJAY, SANGEETHA, NARAYANAN, GEETHA, SAROJAM, SANTHI, RAVEENDRAN, SURESHKUMAR, & SREEDHARAN, HARIHARAN. (2016). ENIGMATIC INV(9): A CASE REPORT ON RARE FINDINGS IN HEMATOLOGICAL MALIGNANCIES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(4), 0-0. SID. https://sid.ir/paper/293219/en

Vancouver: Copy

VIJAY SANGEETHA, NARAYANAN GEETHA, SAROJAM SANTHI, RAVEENDRAN SURESHKUMAR, SREEDHARAN HARIHARAN. ENIGMATIC INV(9): A CASE REPORT ON RARE FINDINGS IN HEMATOLOGICAL MALIGNANCIES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(4):0-0. Available from: https://sid.ir/paper/293219/en

IEEE: Copy

SANGEETHA VIJAY, GEETHA NARAYANAN, SANTHI SAROJAM, SURESHKUMAR RAVEENDRAN, and HARIHARAN SREEDHARAN, “ENIGMATIC INV(9): A CASE REPORT ON RARE FINDINGS IN HEMATOLOGICAL MALIGNANCIES,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293219/en

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