PROTECTIVE EFFECTS OF CO-ENZYME Q10 ON THIOACETAMIDE-INDUCED ACUTE LIVER DAMAGE AND ITS CORRELATION WITH BEHAVIORAL, BIOCHEMICAL, AND PATHOLOGICAL FACTORS

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ASHKANI ESFAHANI SOHEIL; BAGHERI FERESHTEH; EMAMI YASAMAN; ESMAEILZADEH ELMIRA; AZARPIRA NEGAR; HASSANABADI NAZILA; KESHTKAR MARZIEH; FARJAM MOJTABA; KOOHI HOSSEINABADI OMID; NOORAFSHAN ALI

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:8 Page(s): 0-0

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Title

PROTECTIVE EFFECTS OF CO-ENZYME Q10 ON THIOACETAMIDE-INDUCED ACUTE LIVER DAMAGE AND ITS CORRELATION WITH BEHAVIORAL, BIOCHEMICAL, AND PATHOLOGICAL FACTORS

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Keywords

COENZYME Q10

THIOACETAMIDE

ACUTE LIVER FAILURE

BEHAVIORAL SYMPTOMS

HYPERAMMONEMIA

Abstract

Background: Acute liver damage may be followed by biochemical, behavioral, and pathological alterations, which can result in serious complications and even death.Objectives: In this experimental study we determined whether coenzymeQ10 (CoQ10), a common supplementary medicine known to have protective, antioxidative, and anti-inflammatory effects in cells, has any protective effect against THIOACETAMIDE (TAA) - induced liver damage and its related neurobehavioral alterations in rats.Materials and Methods: In this experimental study forty-eight Wistar rats were divided randomly into four groups (n=12): C1 was the control group; C2 received a single-dose of TAA (350mg/kg; intraperitoneally) without any other treatment; E1 received TAA +5 mg/kg CoQ10 (intraperitoneally); and E2 received TAA+10 mg/kg CoQ10. After sacrificing the rats, liver enzymes and plasmaammonia (NH4) were measured and histopathological analyses of the livers were carried out. Elevated-plus-maze, open-field, and forced-swimming tests were also performed to investigate behavioral correlations.Results: The serum levels of alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), and NH4 show significant increases (P<0.05). The groups treated withCoQ10wereshowntohave significantly lower clinical grade of encephalopathy (P=0.001), higher locomotor activity (P=0.000), and lower levels of depression (P=0.000). Furthermore, it was also shown that CoQ10 treatment may lead to significant decreases in scores of centrilobular necrosis, apoptosis, inflammatory cell infiltration, vacuolization, and liver necrosis (P<0.05).Conclusions: Overall, CoQ10 was determined to have positive effects on liver injury and its related behavioral and biochemical changes.

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APA: Copy

ASHKANI ESFAHANI, SOHEIL, BAGHERI, FERESHTEH, AZARPIRA, NEGAR, HASSANABADI, NAZILA, KESHTKAR, MARZIEH, KOOHI HOSSEINABADI, OMID, & NOORAFSHAN, ALI. (2016). PROTECTIVE EFFECTS OF CO-ENZYME Q10 ON THIOACETAMIDE-INDUCED ACUTE LIVER DAMAGE AND ITS CORRELATION WITH BEHAVIORAL, BIOCHEMICAL, AND PATHOLOGICAL FACTORS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(8), 0-0. SID. https://sid.ir/paper/293239/en

Vancouver: Copy

ASHKANI ESFAHANI SOHEIL, BAGHERI FERESHTEH, AZARPIRA NEGAR, HASSANABADI NAZILA, KESHTKAR MARZIEH, KOOHI HOSSEINABADI OMID, NOORAFSHAN ALI. PROTECTIVE EFFECTS OF CO-ENZYME Q10 ON THIOACETAMIDE-INDUCED ACUTE LIVER DAMAGE AND ITS CORRELATION WITH BEHAVIORAL, BIOCHEMICAL, AND PATHOLOGICAL FACTORS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(8):0-0. Available from: https://sid.ir/paper/293239/en

IEEE: Copy

SOHEIL ASHKANI ESFAHANI, FERESHTEH BAGHERI, NEGAR AZARPIRA, NAZILA HASSANABADI, MARZIEH KESHTKAR, OMID KOOHI HOSSEINABADI, and ALI NOORAFSHAN, “PROTECTIVE EFFECTS OF CO-ENZYME Q10 ON THIOACETAMIDE-INDUCED ACUTE LIVER DAMAGE AND ITS CORRELATION WITH BEHAVIORAL, BIOCHEMICAL, AND PATHOLOGICAL FACTORS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 8, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293239/en

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