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Information Journal Paper

Title

HYPNOTIC EFFECT OF OCIMUM BASILICUM ON PENTOBARBITAL-INDUCED SLEEP IN MICE

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  0-0

Abstract

 Background: SLEEP disorders are accompanied by several complications, and currently used soporific drugs can induce unwanted effects such as psychomotor impairment, tolerance, amnesia, and rebound insomnia.Objectives: The present study was carried out to investigate if OCIMUM BASILICUM has a SLEEP-prolonging effect.Materials and Methods: This work was an experimental study on 72 mice which were randomly divided into 9 groups: saline (control); diazepam (3 mg/kg, positive control); hydro-alcoholic extract (HAE) of OCIMUM BASILICUM (25, 50, or 100 mg/kg); ethyl acetate fraction (EAF, 50 mg/kg); n-butanol fraction (NBF, 50 mg/kg); water fraction (WF, 50 mg/kg); and saline containing 10% DMSO (vehicle for EAF and NBF). All the test compounds were injected intraperitoneally (IP) 30 minutes before PENTOBARBITAL administration (30 mg/kg). Duration and latency of PENTOBARBITAL-induced SLEEP were recorded. Also, LD50 of HAE was determined and the cytotoxicity of HAE was tested on neural and fibroblast cells using the MTT assay.Results: HAE increased the duration of PENTOBARBITAL-induced SLEEP at doses of 25, 50, and 100 mg/kg (P<0.001). The hypnotic effect of HAE was comparable to that induced by diazepam. Similarly, WF, EAF, and NBF at 50 mg/kg could increase SLEEP duration. The SLEEP latency was decreased by HAE (P<0.01-P<0.001) and NBF (P<0.001), but not by WF and EAF. The LD50 value for HAE was found to be 2.4 g/kg. HAE had no effect on the viability of neuronal PC12 cells and L929 fibroblast cells.Conclusions: The present data demonstrated that OCIMUM BASILICUM potentiates SLEEPing behaviors without any cytotoxicity. The main component (s) responsible for the hypnotic effects of this plant is most likely a non-polar agent (s) which is found in NBF. Isolation of the active constituents may yield a novel sedative drug.

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APA: Copy

ASKARI, VAHID REZA, BARADARAN RAHIMI, VAFA, GHORBANI, AHMAD, & RAKHSHANDEH, HASSAN. (2016). HYPNOTIC EFFECT OF OCIMUM BASILICUM ON PENTOBARBITAL-INDUCED SLEEP IN MICE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(7), 0-0. SID. https://sid.ir/paper/293249/en

Vancouver: Copy

ASKARI VAHID REZA, BARADARAN RAHIMI VAFA, GHORBANI AHMAD, RAKHSHANDEH HASSAN. HYPNOTIC EFFECT OF OCIMUM BASILICUM ON PENTOBARBITAL-INDUCED SLEEP IN MICE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(7):0-0. Available from: https://sid.ir/paper/293249/en

IEEE: Copy

VAHID REZA ASKARI, VAFA BARADARAN RAHIMI, AHMAD GHORBANI, and HASSAN RAKHSHANDEH, “HYPNOTIC EFFECT OF OCIMUM BASILICUM ON PENTOBARBITAL-INDUCED SLEEP IN MICE,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 7, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293249/en

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