Comparison Between the Cassia Fistula‘ s Emulsion With Polyethylene Glycol (PEG4000) in the Pediatric Functional Constipation: A Randomized Clinical Trial

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ESMAEILIDOOKI MOHAMMADREZA; MOZAFFARPUR SEYYED ALI; MIRZAPOUR MOHADDESE; Shirafkan Hoda; KAMALINEJAD MOHAMMAD; BIJANI ALI

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:7 Page(s): 0-0

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Title

Comparison Between the Cassia Fistula‘ s Emulsion With Polyethylene Glycol (PEG4000) in the Pediatric Functional Constipation: A Randomized Clinical Trial

Author(s)

Keywords

Constipation

Child

Cassia fistula

Polyethylene Glycols

Persian Medicine

Clinical Trial

Abstract

Background: There are few effective drugs for pediatric functional Constipation (FC). Objectives: Comparing the effectiveness of Cassia fistula’ s emulsion (CFE) with Polyethylene glycol (PEG4000) in FC; and evaluation of safety of both drugs in the treatment of FC. Materials and Methods: A randomized open label, prospective, controlled, parallel-group Clinical Trial was carried on 109 Children (M/F: 63/46; mean age SD: 59. 7 28. 8 months) in Amirkola Children’ s hospital, Babol, Iran. The inclusion criteria were based on diagnosis of FC according to the Rome III criteria and age range between 2-15 years. They received CFE or PEG randomly for 4 weeks. Frequencies of defecation, severity of pain, consistency of stool, fecal incontinence and retentive posturing were compared between the two groups and with baselines. Children were counted as improved when they exited from Rome III criteria of FC. Results: Fifty seven patients were assigned to receive PEG and 52 patients received CFE. After 4weeks of medication, 86. 5% of Children in CFE group and 77. 1% in PEG group (RR = 1. 121, CI95%: 0. 939-1. 338) exited from the criteria of FC. All measurable criteria improved in both groups without any significant difference, except in the frequency of defecation that in CFE group (10. 96 5. 7)wassignificantly more than PEG group (6. 9 3. 5) (P < 0. 0001). Compliances of PEG were significantly better in the 2 first weeks (P = 0. 002, 0. 008) but not in third and fourth week (P = 0. 061, 0. 062). None of these two drugs cause clinically significant side effects. Conclusions: CFE can be as effective as PEG in the 4-weeks treatment of Children with FC.

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THE RELATIONSHIP BETWEEN MIZAJ AND ITS INDICES IN PERSIAN MEDICINE

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APA: Copy

ESMAEILIDOOKI, MOHAMMADREZA, Shirafkan, Hoda, KAMALINEJAD, MOHAMMAD, & BIJANI, ALI. (2016). Comparison Between the Cassia Fistula‘ s Emulsion With Polyethylene Glycol (PEG4000) in the Pediatric Functional Constipation: A Randomized Clinical Trial. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(7), 0-0. SID. https://sid.ir/paper/293267/en

Vancouver: Copy

ESMAEILIDOOKI MOHAMMADREZA, Shirafkan Hoda, KAMALINEJAD MOHAMMAD, BIJANI ALI. Comparison Between the Cassia Fistula‘ s Emulsion With Polyethylene Glycol (PEG4000) in the Pediatric Functional Constipation: A Randomized Clinical Trial. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(7):0-0. Available from: https://sid.ir/paper/293267/en

IEEE: Copy

MOHAMMADREZA ESMAEILIDOOKI, Hoda Shirafkan, MOHAMMAD KAMALINEJAD, and ALI BIJANI, “Comparison Between the Cassia Fistula‘ s Emulsion With Polyethylene Glycol (PEG4000) in the Pediatric Functional Constipation: A Randomized Clinical Trial,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 7, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293267/en

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