ACID FOLIC SUPPLEMENTATION IN MAJOR DEPRESSIVE DISORDER TREATMENT: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

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SEPEHRMANESH ZAHRA; OMIDI ABDOLLAH; GHOLAMPOOR NARGES

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Journal: Iranian Red Crescent Medical Journal Year:2017 | Volume:19 | Issue:2 Page(s): 0-0

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Title

ACID FOLIC SUPPLEMENTATION IN MAJOR DEPRESSIVE DISORDER TREATMENT: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

Author(s)

SEPEHRMANESH ZAHRA | OMIDI ABDOLLAH | GHOLAMPOOR NARGES | Issue Writer Certificate

Keywords

MAJOR DEPRESSIVE DISORDER

CITALOPRAM

FOLIC ACID

AUGMENTATION THERAPY

Abstract

Background: AUGMENTATION THERAPY involves the addition of a second drug, such as mood stabilizers, antipsychotics, and nutritional supplements, to a primary antidepressant treatment. Studies on adding FOLIC ACID to a preexisting antidepressive regimen as a form of AUGMENTATION THERAPY have had different and even controversial results.Objectives: This study aimed to determine the effects that adding FOLIC ACID to a pharmaceutical diet with CITALOPRAM has on the treatment of depression.Methods: This double-blind randomized clinical trial was conducted in Kashan, Iran on 90 patients who suffered from depression. Patients were allocated to study groups using random permuted blocks. One group (n=45) received a dosage of 20 mg CITALOPRAM in combination with 2.5mgfolic acid on a daily basis, and the other group (n=45) received the same daily dose of CITALOPRAM with a placebo for eight weeks. To measure the severity of each patient’s depression, the Beck depression inventory II (BDI-II) questionnaire was used prior to starting the antidepressant therapy and was repeated four, six, and eight weeks after beginning the treatment. A reduction from the original BDI-II scores that was greater than 50% was considered to be a response to treatment.Results: The average depression scores before treatment were 30.11±10.41 in the intervention group and 31.24±10.26 in the control group (P=0.6). At the end of the study, the depression scores in the intervention and the control groups were 13.31±6.57 and 19.11±8.59, respectively (P<0.001). A reduction in the average depression scores of the intervention group was statistically significant after six and eight weeks (P=0.01 and P=0.001, respectively). At the end of the study, the frequency of response to treatment was 73.3% in the intervention group and 40.0% in the control group (P<0.001).Conclusions: FOLIC ACID, when used as a complementary therapy, can improve a patient’s response to antidepressants used for the treatment of major depression.

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APA: Copy

SEPEHRMANESH, ZAHRA, OMIDI, ABDOLLAH, & GHOLAMPOOR, NARGES. (2017). ACID FOLIC SUPPLEMENTATION IN MAJOR DEPRESSIVE DISORDER TREATMENT: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(2), 0-0. SID. https://sid.ir/paper/293338/en

Vancouver: Copy

SEPEHRMANESH ZAHRA, OMIDI ABDOLLAH, GHOLAMPOOR NARGES. ACID FOLIC SUPPLEMENTATION IN MAJOR DEPRESSIVE DISORDER TREATMENT: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(2):0-0. Available from: https://sid.ir/paper/293338/en

IEEE: Copy

ZAHRA SEPEHRMANESH, ABDOLLAH OMIDI, and NARGES GHOLAMPOOR, “ACID FOLIC SUPPLEMENTATION IN MAJOR DEPRESSIVE DISORDER TREATMENT: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 2, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293338/en

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