IN VITRO ANTIFUNGAL ACTIVITIES OF GRISEOFULVIN AND TERBINAFINE AGAINST COMMON DERMATOPHYTES

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AMIR RAJAB N.; SHAMS GHAHFAROKHI M.; GHAJARI A.; RAZAGHI ABYANEH M.

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Title

IN VITRO ANTIFUNGAL ACTIVITIES OF GRISEOFULVIN AND TERBINAFINE AGAINST COMMON DERMATOPHYTES

Author(s)

AMIR RAJAB N. | SHAMS GHAHFAROKHI M. | GHAJARI A. | RAZAGHI ABYANEH M. | Issue Writer Certificate

Keywords

DERMATOPHYTESQ3

ANTIFUNGAL DRUGSQ3

TERBINAFINEQ3

GRISEOFULVINQ3

Abstract

Introduction: DERMATOPHYTES are a group of keratinophilic fungi with the ability to invade and parasitize the non-living cornified layer of the skin, where they are localized to the stratum corneum. In this study, in vitro activities of two known ANTIFUNGAL DRUGS, TERBINAFINE (TBF) and GRISEOFULVIN (GR), were tested against reference and native dermatophyte strains.Methods: Agar dilution method was used for determining the anti-dermatophyte activities of the two compounds. The fungi were cultured on sabouraud dextrose agar in presence of different concentrations of the selected compounds.Results: All compounds inhibited the growth of all examined fungi in a dose-dependent manner. The minimal inhibitory concentrations (MICs) of TBF and GR were determined in the range of 0.005- 0.163 mg/ml and 0.78-12.5 mg/ml for all tested DERMATOPHYTES, respectively. The MFC values of above compounds were measured as 0.33 mg/l, 25-200 mg/ml, accordingly.Conclusion: TBF showed the highest antifungal activites against Microsporum canis MC-1 and Microsporum gypseum PTCC 5069, where as GR exerted extreme point activity against Microsporum canis MC-1 and Epidermophyton fluccosum EF-1. TERBINAFINE was shown to be fungicidal at a concentration of 0.165 mg/ml and have suitable antifungal activities in very low concentrations as compared with GR, against T. mentagrophytes, T. rubrum, M. gypseum and E. fluccosum.

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APA: Copy

AMIR RAJAB, N., SHAMS GHAHFAROKHI, M., GHAJARI, A., & RAZAGHI ABYANEH, M.. (2006). IN VITRO ANTIFUNGAL ACTIVITIES OF GRISEOFULVIN AND TERBINAFINE AGAINST COMMON DERMATOPHYTES. HAKIM RESEARCH JOURNAL, 9(1), 28-33. SID. https://sid.ir/paper/29337/en

Vancouver: Copy

AMIR RAJAB N., SHAMS GHAHFAROKHI M., GHAJARI A., RAZAGHI ABYANEH M.. IN VITRO ANTIFUNGAL ACTIVITIES OF GRISEOFULVIN AND TERBINAFINE AGAINST COMMON DERMATOPHYTES. HAKIM RESEARCH JOURNAL[Internet]. 2006;9(1):28-33. Available from: https://sid.ir/paper/29337/en

IEEE: Copy

N. AMIR RAJAB, M. SHAMS GHAHFAROKHI, A. GHAJARI, and M. RAZAGHI ABYANEH, “IN VITRO ANTIFUNGAL ACTIVITIES OF GRISEOFULVIN AND TERBINAFINE AGAINST COMMON DERMATOPHYTES,” HAKIM RESEARCH JOURNAL, vol. 9, no. 1, pp. 28–33, 2006, [Online]. Available: https://sid.ir/paper/29337/en

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